Tìm theo
Huperzine-A
Thuốc Gốc
Small Molecule
Huperzine-A is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has traditionally been used in China for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration, particularly Alzheimer’s disease. Huperzine A is a cholinesterase inhibitor.
Dược Lực Học : Huperzine A is a cholinesterase inhibitor. This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease. There is evidence that huperzine A may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use. In addition, huperzine A has antioxidant and neuroprotective properties that suggest that it may be useful as a disease-modifying treatment for Alzheimer's disease (AD). The drug is currently available as a nutraceutical in this country, and is being used by some U.S. clinicians to treat AD. However, there have been no controlled clinical trials outside China assessing its toxicity and efficacy.
Cơ Chế Tác Dụng : Huperzine-A is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has traditionally been used in China for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration, particularly Alzheimer’s disease. Huperzine A is a cholinesterase inhibitor. As a quasi-irreversible inhibitor of acetylcholinesterase, Huperzine A is a chemical that inhibits the cholinesterase enzyme from breaking down acetylcholine, so increasing both the level and duration of action of the neurotransmitter acetylcholine.
Chỉ Định : Investigated for use/treatment in alzheimer's disease.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05510
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5912039
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