Tìm theo
Histamine Phosphate
Các tên gọi khác (8 ) :
  • 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
  • 4-(2-Aminoethyl)imidazole di-acid phosphate
  • Histamine acid phosphate
  • Histamine biphosphate
  • Histamine dihydrogen phosphate
  • Histamine diphosphate
  • Histamine phosphate (1:2)
  • Histaminum
histamine agents, diagnostic agents
Thuốc Gốc
Small Molecule
CAS: 51-74-1
ATC: V04CG03
ĐG : ALK-Abello Inc. , http://www.alk-abello.com
CTHH: C5H15N3O8P2
PTK: 307.1354
Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H15N3O8P2
Phân tử khối
307.1354
Monoisotopic mass
307.033437495
InChI
InChI=1S/C5H9N3.2H3O4P/c6-2-1-5-3-7-4-8-5;2*1-5(2,3)4/h3-4H,1-2,6H2,(H,7,8);2*(H3,1,2,3,4)
InChI Key
InChIKey=ZHIBQGJKHVBLJJ-UHFFFAOYSA-N
IUPAC Name
2-(1H-imidazol-5-yl)ethan-1-amine; bis(phosphoric acid)
Traditional IUPAC Name
2-(3H-imidazol-4-yl)ethanamine; bis(phosphoric acid)
SMILES
OP(O)(O)=O.OP(O)(O)=O.NCCC1=CN=CN1
Độ tan chảy
139 °C
logP
-3.541
pKa (strongest acidic)
13.5
pKa (Strongest Basic)
9.79
PSA
54.7 Å2
Refractivity
32.23 m3·mol-1
Polarizability
11.98 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
2
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.
Cơ Chế Tác Dụng : Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells. Histamine acts directly on the blood vessels to dilate arteries and capillaries; this action is mediated by both H 1- and H 2-receptors. Capillary dilatation may produce flushing of the face, a decrease in systemic blood pressure, and gastric gland secretion, causing an increased secretion of gastric juice of high acidity. Increased capillary permeability accompanies capillary dilatation, producing an outward passage of plasma protein and fluid into the extracellular spaces, an increase in lymph flow and protein content, and the formation of edema. In addition, histamine has a direct stimulant action on smooth muscle, producing contraction if H 1-receptors are activated, or mostly relaxation if H 2-receptors are activated. Also in humans, the stimulant effect of histamine may cause contraction of the intestinal muscle. However, little effect is noticed on the uterus, bladder, or gallbladder. Histamine has some stimulant effect on duodenal, salivary, pancreatic, bronchial, and lacrimal glands. Histamine also can bind to H3 and H4 receptors which are involved in the CNS/PNS neurotransmitter release and immune system chemotaxis, respectively.
Dược Động Học :
▧ Absorption :
Readily absorbed after parenteral administration
▧ Metabolism :
Primarily hepatic. Histamine is rapidly metabolized by methylation and oxidation. Methylation involves ring methylation and catalyzation by the enzyme histamine-N-methyltransferase, producing N-methylhistamine, which is mostly converted to N-methyl imidazole acetic acid. 2 to 3% excreted as free histamine, 4 to 8% as N-methylhistamine, 42 to 47% as N-methyl imidazole acetic acid, 9 to 11% as imidazole acetic acid, and 16 to 23% as imidazole acetic acid riboside
Độc Tính : LD50=807 mg/kg (mouse, oral). Side effects can lead to hypertension, hypotension, headache, dizziness, nervousness and tachycardia. Large overdoses can lead to seizures.
Chỉ Định : Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
Liều Lượng & Cách Dùng : Liquid - Subcutaneous
Solution - Intradermal
Solution - Topical
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00667
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=65513
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509118
ChemSpider
http://www.chemspider.com/Chemical-Structure.58959.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0268-0248-05
PharmGKB
http://www.pharmgkb.org/drug/PA449880
Drugs.com
http://www.drugs.com/cons/histamine-phosphate-intradermal.html
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