Tìm theo
histamine dihydrochloride
Thuốc Gốc
Small Molecule
CTHH: C5H11Cl2N3
PTK: 184.067
A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H11Cl2N3
Phân tử khối
184.067
Monoisotopic mass
183.033002781
InChI
InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI Key
InChIKey=PPZMYIBUHIPZOS-UHFFFAOYSA-N
IUPAC Name
2-(1H-imidazol-5-yl)ethan-1-amine dihydrochloride
Traditional IUPAC Name
2-(3H-imidazol-4-yl)ethanamine dihydrochloride
SMILES
Cl.Cl.NCCC1=CN=CN1
logP
-1
pKa (strongest acidic)
13.5
pKa (Strongest Basic)
9.79
PSA
54.7 Å2
Refractivity
32.23 m3·mol-1
Polarizability
11.98 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
2
Number of Rings
1
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Histamine dihydrochloride(Ceplene) is developed to maintain the integrity of pivotal immune cells, in particular T cells and natural killer (NK) cells, in patients with cancer. Ceplene treatment aims at facilitating immune-mediated destruction of cancer cells, including leukemic cells, and also at improving the efficiency of T and NK cell-activating agents such as IL-2. Research regarding histamine, the active agent underlying Ceplene, and related clinical results has been the subject of more than 80 presentations at major scientific and clinical meetings, and has been published in more than 300 scientific and clinical articles.
Chỉ Định : Investigated for use/treatment in hepatitis (viral, C), leukemia (myeloid), melanoma, and renal cell carcinoma.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ceplene
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05381
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5818
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=24877934
ChemSpider
http://www.chemspider.com/Chemical-Structure.5613.html
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