Tìm theo
Hexylcaine
Các tên gọi khác (4 ) :
  • Cyclaine
  • Hexilcaina
  • Hexylcaine
  • Hexylcainum
Thuốc gây mê
Thuốc Gốc
Small Molecule
CAS: 532-77-4
CTHH: C16H23NO2
PTK: 261.3593
Hexylcaine hydrochloride, also called cyclaine (Merck) or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function. Hexylcaine has been discontinued in the US market.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H23NO2
Phân tử khối
261.3593
Monoisotopic mass
261.172878985
InChI
InChI=1S/C16H23NO2/c1-13(12-17-15-10-6-3-7-11-15)19-16(18)14-8-4-2-5-9-14/h2,4-5,8-9,13,15,17H,3,6-7,10-12H2,1H3
InChI Key
InChIKey=DKLKMKYDWHYZTD-UHFFFAOYSA-N
IUPAC Name
1-(cyclohexylamino)propan-2-yl benzoate
Traditional IUPAC Name
hexylcaine
SMILES
CC(CNC1CCCCC1)OC(=O)C1=CC=CC=C1
Độ tan chảy
177-178.5
Độ hòa tan
9.71e-03 g/l
logP
3.9
logS
-4.4
pKa (Strongest Basic)
9.87
PSA
38.33 Å2
Refractivity
76.24 m3·mol-1
Polarizability
30.29 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Hexylcaine is a local ester-class anesthetic. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve.
Cơ Chế Tác Dụng : Hexylcaine hydrochloride, also called cyclaine (Merck) or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function. Hexylcaine has been discontinued in the US market. Hexyl caine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel.
Dược Động Học :

▧ Metabolism :
Hydrolyzed by plasma esterases to benzoic acid and other derivatives
▧ Half Life :
<10 minutes
Độc Tính : Symptoms of anesthetic overdose include headache, tinnitus, circumoral and tongue paresthesias, restlessness, talkativeness, facial twitching, convulsions, respiratory arrest, and cardiac depression
Chỉ Định : Used as a local anesthetic for surface application, infiltration or nerve block
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Merck
    Sản phẩm biệt dược : Cyclaine
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00473
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10770
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506241
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C14172
ChemSpider
http://www.chemspider.com/Chemical-Structure.10315.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017670
PharmGKB
http://www.pharmgkb.org/drug/PA164746489
Wikipedia
http://en.wikipedia.org/wiki/Hexylcaine
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