Tìm theo
Hexachlorophene
Các tên gọi khác (39 ) :
  • 2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane
  • 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane
  • 2,2'-Methanediylbis(3,4,6-trichlorophenol)
  • 2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane
  • Acigena
  • Almederm
  • Armohex
  • Bis(2-hydroxy-3,5,6-trichlorophenyl)methane
  • Bis(3,5,6-trichloro-2-hydroxyphenyl)methane
  • Distodin
  • Esaclorofene
  • Exofene
  • Gamophen
  • Gamophene
  • Germa-medica
  • Hexa-germ
  • Hexabalm
  • Hexachlorophenum
  • Hexaclorofeno
  • Hexafen
  • Hexascrub
  • Hexide
  • Nabac
  • Phiso-scrub
  • Phisodan
  • Septi-soft
  • Septisol
  • Septofen
  • Solu-heks
  • Soy-dome
  • Staphene O
  • Ster-zac
  • Steral
  • Steraskin
  • Surgi-cen
  • Surgi-cin
  • Surofene
  • Tersaseptic
  • Turgex
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 70-30-4
ĐG : Bayer Healthcare , http://www.bayerhealthcare.com
CTHH: C13H6Cl6O2
PTK: 406.904
A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H6Cl6O2
Phân tử khối
406.904
Monoisotopic mass
403.849895678
InChI
InChI=1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2
InChI Key
InChIKey=ACGUYXCXAPNIKK-UHFFFAOYSA-N
IUPAC Name
3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol
Traditional IUPAC Name
hexachlorophene
SMILES
OC1=C(CC2=C(O)C(Cl)=CC(Cl)=C2Cl)C(Cl)=C(Cl)C=C1Cl
Độ tan chảy
161-163
Độ sôi
479 °C
Độ hòa tan
140 mg/L (at 25 °C)
logP
7.54
logS
-6
pKa (strongest acidic)
5.15
pKa (Strongest Basic)
-7.4
PSA
40.46 Å2
Refractivity
88.59 m3·mol-1
Polarizability
34.07 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
pKa
4.95
Dược Lực Học : Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Cơ Chế Tác Dụng : A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
Dược Động Học :
▧ Absorption :
Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
▧ Protein binding :
92%
Độc Tính : Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Chỉ Định : For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Liều Lượng & Cách Dùng : Emulsion - Topical
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Hexachlorophene powder
    Giá bán buôn : USD >11.47
    Đơn vị tính : g
  • Biệt dược thương mại : Phisohex 148ml Bottle
    Giá bán buôn : USD >35.46
    Đơn vị tính : bottle
  • Biệt dược thương mại : Tersaseptic cleanser
    Giá bán buôn : USD >0.05
    Đơn vị tính : g
  • Biệt dược thương mại : Phisohex 473ml Bottle
    Giá bán buôn : USD >0.13
    Đơn vị tính : ml
  • Biệt dược thương mại : Phisohex 3% cleanser
    Giá bán buôn : USD >0.18
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty : Dr. August Wolff
    Sản phẩm biệt dược : Aknefug
  • Công ty : Armoxindo
    Sản phẩm biệt dược : Dermisan
  • Công ty : Sanofi
    Sản phẩm biệt dược : pHisoHex
  • Công ty : Davis and Geck
    Sản phẩm biệt dược : Pre-Op
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00756
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3598
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505858
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08039
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00859
ChemSpider
http://www.chemspider.com/Chemical-Structure.3472.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0024-1535-02
PharmGKB
http://www.pharmgkb.org/drug/PA449871
Wikipedia
http://en.wikipedia.org/wiki/Hexachlorophene
RxList
http://www.rxlist.com/cgi/generic2/hexchlorph.htm
Drugs.com
http://www.drugs.com/cdi/hexachlorophene.html
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