Tìm theo
Hesperetin
Các tên gọi khác (8 ) :
  • (-)-(S)-Hesperetin
  • (-)-Hesperetin
  • (S)-2,3-dihydro-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
  • 3',5,7-Trihydroxy-4'-methoxyflavanone
  • Cyanidanon 4'-Methyl Ether 1626
  • Hesperetin
  • Hesperitin
  • YSO2
Thuốc Gốc
Small Molecule
CAS: 520-33-2
CTHH: C16H14O6
PTK: 302.2788
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H14O6
Phân tử khối
302.2788
Monoisotopic mass
302.07903818
InChI
InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1
InChI Key
InChIKey=AIONOLUJZLIMTK-AWEZNQCLSA-N
IUPAC Name
(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
Traditional IUPAC Name
hesperetin
SMILES
COC1=C(O)C=C(C=C1)[C@@H]1CC(=O)C2=C(O)C=C(O)C=C2O1
Độ tan chảy
227.5 °C
Độ hòa tan
273 mg/L
logP
2.60
logS
-3.3
pKa (strongest acidic)
7.92
pKa (Strongest Basic)
-3.9
PSA
96.22 Å2
Refractivity
77.75 m3·mol-1
Polarizability
29.3 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
6
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperetin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions.
Cơ Chế Tác Dụng : Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges. Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.
Chỉ Định : For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Hesperin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01094
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=72281
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507998
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01709
ChemSpider
http://www.chemspider.com/Chemical-Structure.65234.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23418
PharmGKB
http://www.pharmgkb.org/drug/PA164742902
Wikipedia
http://en.wikipedia.org/wiki/Hesperetin
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/hes_0318.shtml
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