Tìm theo
Hedgehog pathway inhibitor
Thuốc Gốc
Small Molecule
Hedgehog pathway inhibitor(Cyclopamine) is naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity, glioblastoma, and as a treatment agent for multiple myeloma. It is currently under phase I of clinical trial.
Cơ Chế Tác Dụng : Hedgehog pathway inhibitor(Cyclopamine) is naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity, glioblastoma, and as a treatment agent for multiple myeloma. It is currently under phase I of clinical trial. Hedgehog pathway inhibitor inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the Smoothened protein. The Hedgehog cell-signaling pathway is normally active during embryonic development in regulating tissue and organ formation. When abnormally activated in adults, however, the Hedgehog pathway is believed to play a central role in allowing the proliferation and survival of certain cancer-causing cells, including in certain deadly cancers such as pancreatic cancer, prostate cancer, small cell lung cancer, breast cancer and certain brain cancers. In addition, recent evidence also points to an important potential role for the Hedgehog pathway in cancer stem cells. Cancer stem cells are progenitor cells suspected to be primarily responsible for tumor growth, survival and metastasis, despite treatment with conventional chemotherapeutic agents.
Chỉ Định : Investigated for use/treatment in basal cell carcinoma and cancer/tumors (unspecified).
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drugbank
http://www.drugbank.ca/drugs/DB05922
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