Tìm theo
HD-O
Thuốc Gốc
Small Molecule
CTHH: C5H11Cl2N3
PTK: 184.067
HD-O is an amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H11Cl2N3
Phân tử khối
184.067
Monoisotopic mass
183.033002781
InChI
InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI Key
InChIKey=PPZMYIBUHIPZOS-UHFFFAOYSA-N
IUPAC Name
2-(1H-imidazol-5-yl)ethan-1-amine dihydrochloride
Traditional IUPAC Name
2-(3H-imidazol-4-yl)ethanamine dihydrochloride
SMILES
Cl.Cl.NCCC1=CN=CN1
logP
-1
pKa (strongest acidic)
13.5
pKa (Strongest Basic)
9.79
PSA
54.7 Å2
Refractivity
32.23 m3·mol-1
Polarizability
11.98 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
2
Number of Rings
1
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : HD-O is an amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Histamine, a natural molecule present in the body, and other molecules in the class known as histamine type-2, or H2, receptor agonists, bind to the H2 receptor on the phagocytes, temporarily preventing the production and release of oxygen free radicals. By preventing the production and release of oxygen free radicals, histamine based therapeutics may protect NK, T, and liver-type NK/ T cells. This protection may allow immune-stimulating agents, such as IL-2 and IFN-alpha, to activate NK cells, T cells and NK/ T cells more effectively, thus enhancing the killing of tumor cells or virally infected cells.
Chỉ Định : Investigated for use/treatment in hepatitis (unspecified), hepatitis (viral, C), and liver disease.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05891
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5818
ChemSpider
http://www.chemspider.com/Chemical-Structure.5613.html
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