Tìm theo
Haloprogin
Các tên gọi khác (5 ) :
  • Haloprogin
  • Haloprogina
  • Haloprogine
  • Haloproginum
  • Halotex
antifungal agents
Thuốc Gốc
Small Molecule
CAS: 777-11-7
ATC: D01AE11
ĐG : Norega Laboratories Inc.
CTHH: C9H4Cl3IO
PTK: 361.391
Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. Haloprogin is no longer available in the United States and has been discontinued.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H4Cl3IO
Phân tử khối
361.391
Monoisotopic mass
359.837241291
InChI
InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2
InChI Key
InChIKey=CTETYYAZBPJBHE-UHFFFAOYSA-N
IUPAC Name
1,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
Traditional IUPAC Name
haloprogin
SMILES
ClC1=CC(Cl)=C(Cl)C=C1OCC#CI
Độ tan chảy
114-115
Độ hòa tan
6.01e-03 g/l
logP
5.3
logS
-4.8
pKa (Strongest Basic)
-5
PSA
9.23 Å2
Refractivity
66.88 m3·mol-1
Polarizability
26.82 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).
Cơ Chế Tác Dụng : Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. Haloprogin is no longer available in the United States and has been discontinued. Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. There is a higher incidence of cutaneous side effects with haloprogin, including irritation, burning, vesiculation (blisters), scaling, and itching. It is generally used when the infection is unresponsive to other antifungals.
Chỉ Định : Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Halotin 1% cream
    Giá bán buôn : USD >1.53
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty : Westwood
    Sản phẩm biệt dược : Aloprogen
  • Công ty : Westwood
    Sản phẩm biệt dược : Halotex
  • Công ty : Schering
    Sản phẩm biệt dược : Mycanden
  • Công ty : Schering-Plough
    Sản phẩm biệt dược : Mycilan
  • Công ty : Meiji
    Sản phẩm biệt dược : Polik
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00793
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3561
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504892
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00339
ChemSpider
http://www.chemspider.com/Chemical-Structure.3440.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194601
PharmGKB
http://www.pharmgkb.org/drug/PA164768737
Wikipedia
http://en.wikipedia.org/wiki/Haloprogin
Drugs.com
http://www.drugs.com/mtm/haloprogin-topical.html
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