Tìm theo
Halobetasol Propionate
Các tên gọi khác (5 ) :
  • Miracorten
  • SID50112705
  • Ulobetasol
  • Ulobétasol
  • Ulobetasolum
Thuốc Gốc
Small Molecule
CAS: 66852-54-8
ATC: D07AC21
ĐG : Actavis Group , http://www.actavis.com
CTHH: C25H31ClF2O5
PTK: 484.96
Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. It is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C25H31ClF2O5
Phân tử khối
484.96
Monoisotopic mass
484.182808219
InChI
InChI=1S/C25H31ClF2O5/c1-5-21(32)33-25(20(31)12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15?,16?,18-,19?,22?,23?,24-,25-/m0/s1
InChI Key
InChIKey=BDSYKGHYMJNPAB-YKQIDFLYSA-N
IUPAC Name
(1R,8S,13S,14R)-14-(2-chloroacetyl)-1,8-difluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl propanoate
Traditional IUPAC Name
(1R,8S,13S,14R)-14-(2-chloroacetyl)-1,8-difluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl propanoate
SMILES
[H][C@]1(F)CC2C3C[C@H](C)[C@](OC(=O)CC)(C(=O)CCl)C3(C)CC(O)[C@]2(F)C2(C)C=CC(=O)C=C12
Độ hòa tan
Mostly insoluble
logP
2.9
logS
-4.8
pKa (strongest acidic)
13.55
pKa (Strongest Basic)
-3.4
PSA
80.67 Å2
Refractivity
119.15 m3·mol-1
Polarizability
47.93 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. It is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.
Dược Động Học :
▧ Absorption :
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Inflammation and/or other disease processes in the skin may increase percutaneous absorption.
Chỉ Định : For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Liều Lượng & Cách Dùng : Cream - Topical
Ointment - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Fougera
    Sản phẩm biệt dược : Halobetasol
  • Công ty : Glenmark
    Sản phẩm biệt dược : Halovate
  • Công ty : Aamorb
    Sản phẩm biệt dược : Hobs
  • Công ty : Ranbaxy
    Sản phẩm biệt dược : Ultravate
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00596
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=48175
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506187
ChemSpider
http://www.chemspider.com/Chemical-Structure.43819.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0713-0639-15
PharmGKB
http://www.pharmgkb.org/drug/PA164768832
RxList
http://www.rxlist.com/cgi/generic3/halobetasol.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ult1649.shtml
Drugs.com
http://www.drugs.com/cdi/halobetasol-cream.html
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