Tìm theo
Guanidine
Các tên gọi khác (7 ) :
  • Aminomethanamidine
  • Gu
  • Guanidin
  • GUANIDINE
  • H2N-C(=NH)-NH2
  • Imidourea
  • Iminourea
Thuốc Gốc
Small Molecule
CAS: 113-00-8
ATC: A07AB03
ĐG : Schering Corp. , http://www.schering.de
CTHH: CH5N3
PTK: 59.0705
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
CH5N3
Phân tử khối
59.0705
Monoisotopic mass
59.048347175
InChI
InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4)
InChI Key
InChIKey=ZRALSGWEFCBTJO-UHFFFAOYSA-N
IUPAC Name
guanidine
Traditional IUPAC Name
guanidine
SMILES
NC(N)=N
Độ tan chảy
50 °C
Độ hòa tan
1840 mg/L (at 20 °C)
logP
-0.6
logS
-0.71
pKa (Strongest Basic)
12.55
PSA
75.89 Å2
Refractivity
25.86 m3·mol-1
Polarizability
5.57 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
12.5
Dược Lực Học : Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Dược Động Học :
▧ Absorption :
Rapidly absorbed and distributed
▧ Metabolism :
Not metabolized.
▧ Half Life :
7-8 hours
Độc Tính : LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Chỉ Định : For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Tương Tác Thuốc :
  • Tacrine The acetylcholinesterase inhibitor, Tacrine, may increase the adverse/toxic effects of Guanidine, a cholinergic agonist. Monitor for increased cholinergic effects and toxicity.
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00536
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3520
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507543
ChemSpider
http://www.chemspider.com/Chemical-Structure.3400.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0085-0492-01
PharmGKB
http://www.pharmgkb.org/drug/PA164781028
Wikipedia
http://en.wikipedia.org/wiki/Guanidine
Drugs.com
http://www.drugs.com/mtm/guanidine.html
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