Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Monoisotopic mass
59.048347175
InChI
InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4)
InChI Key
InChIKey=ZRALSGWEFCBTJO-UHFFFAOYSA-N
Traditional IUPAC Name
guanidine
Độ hòa tan
1840 mg/L (at 20 °C)
pKa (Strongest Basic)
12.55
Refractivity
25.86 m3·mol-1
Dược Lực Học :
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Dược Động Học :
▧ Absorption :
Rapidly absorbed and distributed
▧ Metabolism :
Not metabolized.
▧ Half Life :
7-8 hours
Độc Tính :
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Chỉ Định :
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Tương Tác Thuốc :
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Tacrine
The acetylcholinesterase inhibitor, Tacrine, may increase the adverse/toxic effects of Guanidine, a cholinergic agonist. Monitor for increased cholinergic effects and toxicity.
Dữ Kiện Thương Mại
Giá thị trường
-
Giá bán buôn : USD >0.25
Đơn vị tính : tablet
Tài Liệu Tham Khảo Thêm
National Drug Code Directory