Tìm theo
Guanadrel
Các tên gọi khác (2) :
  • Guanadrel
  • Guanadrelum
antihypertensive agents
Thuốc Gốc
Small Molecule
CAS: 22195-34-2
ĐG : Pharmaceutical Utilization Management Program VA Inc.
CTHH: C10H19N3O2
PTK: 213.2768
Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H19N3O2
Phân tử khối
213.2768
Monoisotopic mass
213.147726867
InChI
InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13)
InChI Key
InChIKey=HPBNRIOWIXYZFK-UHFFFAOYSA-N
IUPAC Name
2-{1,4-dioxaspiro[4.5]decan-2-ylmethyl}guanidine
Traditional IUPAC Name
guanadrel
SMILES
NC(N)=NCC1COC2(CCCCC2)O1
Độ tan chảy
213.5-215
Độ hòa tan
1.93e+00 g/l
logP
0.6
logS
-2
pKa (strongest acidic)
19.85
pKa (Strongest Basic)
12.56
PSA
82.86 Å2
Refractivity
56.54 m3·mol-1
Polarizability
23.23 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanadrel works by controlling nerve impulses along certain nerve pathways. As a result, it relaxes the blood vessels so that blood passes through them more easily. This helps to lower blood pressure.
Cơ Chế Tác Dụng : Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter. Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter. Guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation. The reduction in neurotransmitter release in response to sympathetic nerve stimulation, as a result of catecholamine depletion, leads to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position.
Dược Động Học :
▧ Absorption :
Rapidly and readily absorbed from the gastrointestinal tract.
▧ Protein binding :
Low, approximately 20%
▧ Metabolism :
Primarily hepatic
▧ Half Life :
10 hours
Độc Tính : Side effects include dizziness, drowsiness, headache, constipation, diarrhea, gas pains, loss of appetite, fatigue, and nasal congestion.
Chỉ Định : Used to treat and control hypertension.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Cutter
    Sản phẩm biệt dược : Anarel
  • Công ty : Pennwalt
    Sản phẩm biệt dược : Hylorel
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00226
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=38521
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506457
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00607
ChemSpider
http://www.chemspider.com/Chemical-Structure.35305.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745308
Drugs.com
http://www.drugs.com/mtm/guanadrel.html
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