Tìm theo
Guaifenesin
Các tên gọi khác (4 ) :
  • Glyceryl guaiacolate
  • guaiphenesin
  • Hustosil
  • Robitussin
Thuốc dùng điều trị mắt, tai mũi họng
Thuốc Gốc
Small Molecule
CAS: 93-14-1
ATC: R05CA03
ĐG : Adams Labs
CTHH: C10H14O4
PTK: 198.2158
An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H14O4
Phân tử khối
198.2158
Monoisotopic mass
198.089208936
InChI
InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3
InChI Key
InChIKey=HSRJKNPTNIJEKV-UHFFFAOYSA-N
IUPAC Name
3-(2-methoxyphenoxy)propane-1,2-diol
Traditional IUPAC Name
guaifenesin
SMILES
COC1=CC=CC=C1OCC(O)CO
Độ tan chảy
78.5-79
Độ sôi
215 °C at 1.90E+01 mm Hg
Độ hòa tan
5E+004 mg/L (at 25 °C)
logP
1.39
logS
-1.1
pKa (strongest acidic)
13.62
pKa (Strongest Basic)
-3
PSA
58.92 Å2
Refractivity
51.24 m3·mol-1
Polarizability
20.59 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
Cơ Chế Tác Dụng : An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem] Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing.
Dược Động Học :
▧ Absorption :
Rapidly absorbed from the GI tract
▧ Metabolism :
Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.
▧ Half Life :
1 hour
Độc Tính : LD50 1510 mg/kg (rat, oral)
Chỉ Định : Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Liều Lượng & Cách Dùng : Liquid - Oral
Syrup - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Duratuss G
  • Công ty : Cypress
    Sản phẩm biệt dược : Ganidin
  • Công ty : Kyoto Yakuhin
    Sản phẩm biệt dược : Hustosil
  • Công ty : Hyrex
    Sản phẩm biệt dược : Hytuss
  • Sản phẩm biệt dược : Mucinex
  • Công ty : Wyeth
    Sản phẩm biệt dược : Robitussin
  • Công ty :
    Sản phẩm biệt dược : Scot-tussin Expectorant
  • Công ty :
    Sản phẩm biệt dược : Sinumist-SR
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00874
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3516
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508004
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00337
ChemSpider
http://www.chemspider.com/Chemical-Structure.3396.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/63824-023-36
PharmGKB
http://www.pharmgkb.org/drug/PA449818
Wikipedia
http://en.wikipedia.org/wiki/Guaifenesin
RxList
http://www.rxlist.com/cgi/generic2/guaifen.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tus1463.shtml
Drugs.com
http://www.drugs.com/guaifenesin.html
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