Dược Động Học :
▧ Absorption :
Absorption of is rapid and complete, though oral bioavailability is reduced to about 60% as a result of first pass metabolism.
▧ Protein binding :
▧ Metabolism :
Primarily hepatic; undergoes N -demethylation and aromatic ring oxidation followed by conjugation. Animal studies suggest that some of the metabolites may have 5-HT 3 receptor antagonist activity.
▧ Route of Elimination :
The remainder of the dose is excreted as metabolites, 48% in the urine and 38% in the feces.
▧ Half Life :
4-6 hours in healthy patients, 9-12 hours in cancer patients
▧ Clearance :
* 0.52 L/h/kg [Cancer Patients with 1 mg bid for 7 days]
* 0.41 L/h/kg [Healthy subject with a single 1 mg dose]