Tìm theo
Gonadorelin
Các tên gọi khác (9 ) :
  • Fertagyl
  • GnRH
  • GnRH-I
  • Gonadoliberin I
  • Gonadorelin
  • Gonadorelina
  • Gonadoréline
  • Gonadorelinum
  • Luteinizing Hormone-releasing Factor Diacetate Tetrahydrate
Thuốc Gốc
Small Molecule
CAS: 6918-09-8
ATC: H01CA01, V04CM01
ĐG : Hospira Inc. , http://www.hospira.com
CTHH: C55H75N17O13
PTK: 1182.2901
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C55H75N17O13
Phân tử khối
1182.2901
Monoisotopic mass
1181.573025571
InChI
InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)
InChI Key
InChIKey=XLXSAKCOAKORKW-UHFFFAOYSA-N
IUPAC Name
N-(1-{2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl}-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl)-2-{2-[2-(3-hydroxy-2-{2-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamide
Traditional IUPAC Name
N-{1-[2-(carbamoylmethylcarbamoyl)pyrrolidin-1-yl]-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl}-2-{2-[2-(3-hydroxy-2-{2-[3-(3H-imidazol-4-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamide
SMILES
CC(C)CC(NC(=O)CNC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(=O)C(CC1=CNC2=CC=CC=C12)NC(=O)C(CC1=CN=CN1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O
Độ hòa tan
1 mg/mL
logP
-3.6
logS
-4.3
pKa (strongest acidic)
9.47
pKa (Strongest Basic)
11.16
PSA
474.63 Å2
Refractivity
302.51 m3·mol-1
Polarizability
121.19 Å3
Rotatable Bond Count
31
H Bond Acceptor Count
17
H Bond Donor Count
16
Physiological Charge
2
Number of Rings
6
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Cơ Chế Tác Dụng : Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
Dược Động Học :
▧ Absorption :
Rapidly absorbed when injected
▧ Metabolism :
Rapidly hydrolyzed to inactive peptide components
▧ Half Life :
Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes
Độc Tính : LD50>3000 mg/kg (rat, oral)
Chỉ Định : For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Liều Lượng & Cách Dùng : Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Intrapharm
    Sản phẩm biệt dược : Gonadorelin
  • Công ty : Intrapharm
    Sản phẩm biệt dược : HRF
  • Sản phẩm biệt dược : Hypocrine
  • Công ty : Sanofi-Aventis
    Sản phẩm biệt dược : Kryptocur
  • Công ty : Ferring
    Sản phẩm biệt dược : Lutrelef
  • Công ty : Ferring
    Sản phẩm biệt dược : Lutrepulse
  • Công ty : Sanofi-Aventis
    Sản phẩm biệt dược : Relefact
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00644
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=36523
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506144
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07607
ChemSpider
http://www.chemspider.com/Chemical-Structure.33562.html
PharmGKB
http://www.pharmgkb.org/drug/PA449801
Wikipedia
http://en.wikipedia.org/wiki/Gonadorelin
RxList
http://www.rxlist.com/cgi/generic2/gonadorelin.htm
Drugs.com
http://www.drugs.com/cdi/gonadorelin.html
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