Tìm theo
Glycine
Các tên gọi khác (13 ) :
  • Aminoacetic acid
  • Aminoessigsaeure
  • Aminoethanoic acid
  • G
  • Gly
  • Glycin
  • Glycine
  • Glycocoll
  • Glykokoll
  • Glyzin
  • H2N-CH2-COOH
  • Hgly
  • Leimzucker
Thực phẩm chức năng
Thuốc Gốc
Small Molecule
CAS: 56-40-6
ATC: B03AA01, B05CX03
ĐG : Amend
CTHH: C2H5NO2
PTK: 75.0666
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2H5NO2
Phân tử khối
75.0666
Monoisotopic mass
75.032028409
InChI
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI Key
InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N
IUPAC Name
2-aminoacetic acid
Traditional IUPAC Name
glycine
SMILES
NCC(O)=O
Độ tan chảy
262 dec °C
Độ hòa tan
2.49E+005 mg/L (at 25 °C)
logP
-3.21
logS
0.87
pKa (strongest acidic)
2.31
pKa (Strongest Basic)
9.24
PSA
63.32 Å2
Refractivity
16 m3·mol-1
Polarizability
6.65 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
2.37 (at 20 °C)
Dược Lực Học : Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.
Cơ Chế Tác Dụng : A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem] In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.
Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS.
Dược Động Học :
▧ Absorption :
Absorbed from the small intestine via an active transport mechanism.
▧ Metabolism :
Hepatic
Độc Tính : ORL-RAT LD50 7930 mg/kg, SCU-RAT LD50 5200 mg/kg, IVN-RAT LD50 2600 mg/kg, ORL-MUS LD50 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.
Chỉ Định : Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.
Liều Lượng & Cách Dùng : Liquid - Irrigation
Solution - Intraperitoneal
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Gyn-Hydralin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00145
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=750
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508219
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00037
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00011
ChemSpider
http://www.chemspider.com/Chemical-Structure.730.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0338-0289-47
PharmGKB
http://www.pharmgkb.org/drug/PA449789
Wikipedia
http://en.wikipedia.org/wiki/Glycine
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/gly_0127.shtml
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