Tìm theo
Glutathione
Các tên gọi khác (7 ) :
  • 5-L-Glutamyl-L-cysteinylglycine
  • gamma-L-Glutamyl-L-cysteinyl-glycine
  • Glutathione
  • Glutathione-SH
  • GSH
  • N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
  • Reduced glutathione
Thuốc cấp cứu & giải độc
Thuốc Gốc
Small Molecule
CAS: 70-18-8
ATC: V03AB32
ĐG : Letco Medical Inc. , http://www.letcomedical.com
CTHH: C10H17N3O6S
PTK: 307.323
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H17N3O6S
Phân tử khối
307.323
Monoisotopic mass
307.083805981
InChI
InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
InChI Key
InChIKey=RWSXRVCMGQZWBV-WDSKDSINSA-N
IUPAC Name
(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid
Traditional IUPAC Name
(2S)-2-amino-4-{[(1R)-1-(carboxymethylcarbamoyl)-2-sulfanylethyl]carbamoyl}butanoic acid
SMILES
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
Độ tan chảy
195 °C
Độ hòa tan
8.79e-01 g/l
logP
-6.4
logS
-2.5
pKa (strongest acidic)
1.94
pKa (Strongest Basic)
9.22
PSA
158.82 Å2
Refractivity
69.11 m3·mol-1
Polarizability
29.11 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
7
H Bond Donor Count
6
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Cơ Chế Tác Dụng : A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. [PubChem] Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It is also important as a hydrophilic molecule that is added to lipophilic toxins and waste in the liver during biotransformation before they can become part of the bile. Glutathione is also needed for the detoxification of methylglyoxal, a toxin produced as a by-product of metabolism. This detoxification reaction is carried out by the glyoxalase system. Glyoxalase I catalyzes the conversion of methylglyoxal and reduced glutathione to S-D-Lactoyl-glutathione. Glyoxalase II catalyzes the conversion of S-D-Lactoyl Glutathione to Reduced Glutathione and D-lactate. GSH is known as a cofactor in both conjugation reactions and reduction reactions, catalyzed by glutathione S-transferase enzymes in cytosol, microsomes, and mitochondria. However, it is capable of participating in non-enzymatic conjugation with some chemicals, as it is hypothesized to do to a significant extent with n-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450 reactive metabolite formed by toxic overdose of acetaminophen. Glutathione in this capacity binds to NAPQI as a suicide substrate and in the process detoxifies it, taking the place of cellular protein sulfhydryl groups which would otherwise be toxically adducted. The preferred medical treatment to an overdose of this nature, whose efficacy has been consistently supported in literature, is the administration (usually in atomized form) of N-acetylcysteine, which is used by cells to replace spent GSSG and allow a usable GSH pool.
Dược Động Học :
▧ Absorption :
Research suggests that glutathione is not orally bioactive, and that very little of oral glutathione tablets or capsules is actually absorbed by the body.
Độc Tính : ORL-MUS LD50 5000 mg/kg, IPR-MUS LD50 4020 mg/kg, SCU-MUS LD50 5000 mg/kg, IVN-RBT LD50 > 2000 mg/kg, IMS-MUS LD50 4000 mg/kg
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Isethion
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00143
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=124886
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504598
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00051
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00014
ChemSpider
http://www.chemspider.com/Chemical-Structure.111188.html
PharmGKB
http://www.pharmgkb.org/drug/PA449780
Wikipedia
http://en.wikipedia.org/wiki/Glutathione
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/glu_0126.shtml
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