Tìm theo
Gentian Violet
Các tên gọi khác (10 ) :
  • Crystal Violet
  • Crystal violet carbocation
  • Crystal violet ion(1)
  • Crystal violet(1+)
  • Gentian violet carbocation
  • Gentian violet cation
  • Gentian violet(1+)
  • Methyl Violet 10B
  • Pyoctanin
  • Pyoctanine
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 14426-25-6
ATC: D01AE02
ĐG : Humco , http://www.humco.com
CTHH: C25H30N3
PTK: 372.5258
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C25H30N3
Phân tử khối
372.5258
Monoisotopic mass
372.243972975
InChI
InChI=1S/C25H30N3/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6/h7-18H,1-6H3/q+1
InChI Key
InChIKey=LGLFFNDHMLKUMI-UHFFFAOYSA-N
IUPAC Name
4-{bis[4-(dimethylamino)phenyl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium
Traditional IUPAC Name
gentian violet
SMILES
CN(C)C1=CC=C(C=C1)C(C1=CC=C(C=C1)N(C)C)=C1C=CC(C=C1)=[N+](C)C
Độ tan chảy
215 °C
Độ hòa tan
4 mg/mL
logP
3.18
logS
-5.3
pKa (Strongest Basic)
4.83
PSA
9.49 Å2
Refractivity
146 m3·mol-1
Polarizability
45.6 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
Cơ Chế Tác Dụng : A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. [PubChem] In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.
Dược Động Học :

▧ Metabolism :
Primarily hepatic, mostly demethylation
Độc Tính : LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Chỉ Định : For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Liều Lượng & Cách Dùng : Liquid - Topical
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00406
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3468
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505353
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01046
ChemSpider
http://www.chemspider.com/Chemical-Structure.3349.html
PharmGKB
http://www.pharmgkb.org/drug/PA449755
Wikipedia
http://en.wikipedia.org/wiki/Gentian_Violet
Drugs.com
http://www.drugs.com/cons/gentian-violet-topical.html
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