Tìm theo
Gallamine Triethiodide
Các tên gọi khác (5 ) :
  • Flaxedil
  • Gallamin triethiodid
  • Gallamini Triethiodidum
  • Triéthiodure de Gallamine
  • Trietioduro de galamina
neuromuscular nondepolarizing agents, nicotinic antagonists, muscle relaxant skeletal
Thuốc Gốc
Small Molecule
CAS: 65-29-2
ATC: M03AC02
CTHH: C30H60I3N3O3
PTK: 891.5291
A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C30H60I3N3O3
Phân tử khối
891.5291
Monoisotopic mass
891.176873061
InChI
InChI=1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
InChI Key
InChIKey=REEUVFCVXKWOFE-UHFFFAOYSA-K
IUPAC Name
(2-{2,3-bis[2-(triethylazaniumyl)ethoxy]phenoxy}ethyl)triethylazanium triiodide
Traditional IUPAC Name
(2-{2,3-bis[2-(triethylaminio)ethoxy]phenoxy}ethyl)triethylazanium triiodide
SMILES
[I-].[I-].[I-].CC[N+](CC)(CC)CCOC1=CC=CC(OCC[N+](CC)(CC)CC)=C1OCC[N+](CC)(CC)CC
Độ tan chảy
152-153
Độ hòa tan
Soluble
logP
3.5
logS
-8.3
pKa (Strongest Basic)
-4.5
PSA
27.69 Å2
Refractivity
189.98 m3·mol-1
Polarizability
63.43 Å3
Rotatable Bond Count
21
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
3
Number of Rings
1
Bioavailability
0
Dược Lực Học : Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.
Cơ Chế Tác Dụng : A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198) It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.
Chỉ Định : For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Sanofi-Aventis
    Sản phẩm biệt dược : Flaxedil
  • Công ty : Yoo Young
    Sản phẩm biệt dược : Myraxan
  • Công ty : Carlo Erba
    Sản phẩm biệt dược : Sincurarina
  • Công ty :
    Sản phẩm biệt dược : Tricuran
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00483
PharmGKB
http://www.pharmgkb.org/drug/PA164745088
Wikipedia
http://en.wikipedia.org/wiki/Gallamine_triethiodide
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