Tìm theo
Gadoversetamide
Các tên gọi khác (5 ) :
  • Gadoversetamid
  • Gadoversetamida
  • Gadoversetamide
  • Gadoversetamidum
  • OptiMARK
contrast media
Thuốc Gốc
Small Molecule
CAS: 131069-91-5
ATC: V08CA06
ĐG : Mallinckrodt Inc. , http://www.mallinckrodt.com
CTHH: C20H34GdN5O10
PTK: 661.76
Gadoversetamide is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver. It is marketed under the trade name OptiMARK.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H34GdN5O10
Phân tử khối
661.76
Monoisotopic mass
662.154667866
InChI
InChI=1S/C20H37N5O10.Gd/c1-34-9-3-21-16(26)11-24(14-19(30)31)7-5-23(13-18(28)29)6-8-25(15-20(32)33)12-17(27)22-4-10-35-2;/h3-15H2,1-2H3,(H,21,26)(H,22,27)(H,28,29)(H,30,31)(H,32,33);/q;+3/p-3
InChI Key
InChIKey=HBEAOBRDTOXWRZ-UHFFFAOYSA-K
IUPAC Name
gadolinium(3+) ion 2-[bis({2-[(carboxylatomethyl)({[(2-methoxyethyl)carbamoyl]methyl})amino]ethyl})amino]acetate
Traditional IUPAC Name
gadolinium(3+) 2-[bis({2-[(carboxylatomethyl)({[(2-methoxyethyl)carbamoyl]methyl})amino]ethyl})amino]acetate
SMILES
[Gd+3].COCCNC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)NCCOC)CC([O-])=O)CC([O-])=O
Độ hòa tan
2.98e+00 g/l
logP
-7
logS
-2.4
pKa (strongest acidic)
2.32
pKa (Strongest Basic)
8.97
PSA
206.77 Å2
Refractivity
154.49 m3·mol-1
Polarizability
49.81 Å3
Rotatable Bond Count
22
H Bond Acceptor Count
13
H Bond Donor Count
2
Physiological Charge
-2
Number of Rings
0
Bioavailability
0
Cơ Chế Tác Dụng : Gadoversetamide is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver. It is marketed under the trade name OptiMARK. Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. MR images are based primarily on proton density and proton relaxation dynamics. MR instruments are sensitive to two different relaxation processes, the T1 (spin-lattice or longitudinal relaxation time) and T2 (spin-spin or transverse relaxation time). Paramagnetic agents contain one or more unpaired electrons that enhance the T1 and T2 relaxation rates of protons in their molecular environment. In MRI, visualization of normal and pathological brain, spinal and hepatic tissue depends in part on variations in the radio frequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in T2. When placed in a magnetic field, gadoversetamide shortens the T1 and T2 relaxation times in tissues where it accumulates. At the recommended dose, the effect is primarily on T1 relaxation time, and produces an increase in signal intensity (brightness). Gadoversetamide does not cross the intact blood-brain barrier; therefore, it does not accumulate in normal brain tissue or in CNS lesions that may have a normal blood-brain barrier (e.g., cysts, mature post-operative scars). Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadoversetamide in lesions such as neoplasms, abscesses, and subacute infarcts.
Dược Động Học :

▧ Volume of Distribution :
* 162 ± 25 mL/kg [normal subjects]
▧ Metabolism :
None detected
▧ Route of Elimination :
The mean cumulative urinary excretion of gadoversetamide at 72 hours was approximately 93.5% for renal impaired patients and 95.8% for subjects with normal renal function
▧ Half Life :
Distribution 13.3 ± 6.8 (mean) minutes, elimination 103.6 ± 19.5 (mean) minutes.
▧ Clearance :
* 72 +/- 16.3 mL/hr/kg [healthy]
Chỉ Định : Gadoversetamide is an MRI contrast agent used for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Mallinckrodt
    Sản phẩm biệt dược : OptiMARK
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00538
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=444013
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504481
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01646
ChemSpider
http://www.chemspider.com/Chemical-Structure.392041.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0019-1177-02
PharmGKB
http://www.pharmgkb.org/drug/PA164743703
Wikipedia
http://en.wikipedia.org/wiki/Gadoversetamide
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