Tìm theo
Gadodiamide
Các tên gọi khác (7 ) :
  • Gadodiamida
  • Gadodiamide
  • Gadodiamide hydrate
  • Gadodiamidum
  • Gadolinium [bis(2-{(carboxylatomethyl)[2-(methylamino)-2-oxoethyl]amino}ethyl)amino]acetate--water (1/1)
  • Gadolinium 5,8-bis(carboxylatomethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oate hydrate
  • Omniscan
Thuốc Gốc
Small Molecule
CAS: 122795-43-1
ATC: V08CA03
ĐG : Amersham Health Inc.
CTHH: C16H28GdN5O9
PTK: 591.67
Gadodiamide is a gadolinium based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. It is commonly marketed under the trade name Omniscan. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H28GdN5O9
Phân tử khối
591.67
Monoisotopic mass
592.112803052
InChI
InChI=1S/C16H29N5O8.Gd.H2O/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);;1H2/q;+3;/p-3
InChI Key
InChIKey=XPCLDSMKWNNKOM-UHFFFAOYSA-K
IUPAC Name
gadolinium(3+) ion 2-[bis({2-[(carboxylatomethyl)[(methylcarbamoyl)methyl]amino]ethyl})amino]acetate hydrate
Traditional IUPAC Name
gadolinium(3+) 2-[bis({2-[(carboxylatomethyl)[(methylcarbamoyl)methyl]amino]ethyl})amino]acetate hydrate
SMILES
O.[Gd+3].CNC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)NC)CC([O-])=O)CC([O-])=O
logP
-6.9
pKa (strongest acidic)
2.36
pKa (Strongest Basic)
8.97
PSA
188.31 Å2
Refractivity
132.4 m3·mol-1
Polarizability
39.34 Å3
Rotatable Bond Count
16
H Bond Acceptor Count
11
H Bond Donor Count
2
Physiological Charge
-2
Number of Rings
0
Bioavailability
0
Cơ Chế Tác Dụng : Gadodiamide is a gadolinium based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. It is commonly marketed under the trade name Omniscan. [Wikipedia] Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. Paramagnetic agents have unpaired electrons that generate a magnetic field about 700 times larger than the proton's field, thus disturbing the proton's local magnetic field. When the local magnetic field around a proton is disturbed, its relaxation process is altered. MR images are based on proton density and proton relaxation dynamics. MR instruments can record 2 different relaxation processes, the T1 (spin-lattice or longitudinal relaxation time) and the T2 (spin-spin or transverse relaxation time). In magnetic resonance imaging (MRI), visualization of normal and pathological brain tissue depends in part on variations in the radiofrequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in the T2. When placed in a magnetic field, gadodiamide shortens both the T1 and the T2 relaxation times in tissues where it accumulates. At clinical doses, gadodiamide primarily affects the T1 relaxation time, thus producing an increase in signal intensity. Gadodiamide does not cross the intact blood-brain barrier; therefore, it does not accumulate in normal brain tissue or in central nervous system (CNS) lesions that have not caused an abnormal blood-brain barrier (e.g., cysts, mature post-operative scars). Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadodiamide in lesions such as neoplasms, abscesses, and subacute infarcts.
Dược Động Học :

▧ Volume of Distribution :
* 200 ± 61 mL/kg
▧ Metabolism :
There is no detectable biotransformation or decomposition of gadodiamide.
▧ Route of Elimination :
Gadodiamide is eliminated primarily in the urine.
▧ Half Life :
Two-compartment model with mean distribution and elimination half-lives (reported as mean ± SD) of 3.7 ± 2.7 minutes and 77.8 ± 16 minutes, respectively.
▧ Clearance :
* Renal cl=1.7 mL/min/kg * Plasma cl=1.8 mL/min/kg
Chỉ Định : For intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Omniscan
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00225
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=60754
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504789
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C13106
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01645
ChemSpider
http://www.chemspider.com/Chemical-Structure.54756.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0407-0690-05
PharmGKB
http://www.pharmgkb.org/drug/PA164784027
Wikipedia
http://en.wikipedia.org/wiki/Gadodiamide
RxList
http://www.rxlist.com/cgi/generic3/omniscan.htm
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