Tìm theo
Fulvestrant
Các tên gọi khác (2) :
  • ICI 182,780
  • SID29215034
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 129453-61-8
ATC: L02BA03
ĐG : AstraZeneca Inc. , http://www.astrazeneca.ca
CTHH: C32H47F5O3S
PTK: 606.771
Fulvestrant is a drug treatment of hormone receptor-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C32H47F5O3S
Phân tử khối
606.771
Monoisotopic mass
606.316607085
InChI
InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29?,30+,41?/m1/s1
InChI Key
InChIKey=VWUXBMIQPBEWFH-LQKBAPIOSA-N
IUPAC Name
(1S,9R,11S,14S,15S)-15-methyl-9-{9-[(4,4,5,5,5-pentafluoropentane)sulfinyl]nonyl}tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol
Traditional IUPAC Name
(1S,9R,11S,14S,15S)-15-methyl-9-[9-(4,4,5,5,5-pentafluoropentanesulfinyl)nonyl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol
SMILES
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])C2[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=CC(O)=CC=C12
Độ hòa tan
6.72e-03 g/l
logP
8.9
logS
-5
pKa (strongest acidic)
10.32
pKa (Strongest Basic)
-0.88
PSA
57.53 Å2
Refractivity
155.34 m3·mol-1
Polarizability
65.64 Å3
Rotatable Bond Count
15
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Fulvestrant for intramuscular administration is an estrogen receptor antagonist without known agonist effects.
Cơ Chế Tác Dụng : Fulvestrant is a drug treatment of hormone receptor-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. Fulvestrant competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, fulvestrant binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, fulvestrant degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines.
Dược Động Học :

▧ Volume of Distribution :
* 3 to 5 L/kg
▧ Protein binding :
99% (mainly VLDL, LDL, and HDL)
▧ Metabolism :
Metabolism of fulvestrant appears to involve combinations of a number of possible biotransformation pathways analogous to those of endogenous steroids, including oxidation, aromatic hydroxylation, conjugation with glucuronic acid and/or sulphate at the 2, 3 and 17 positions of the steroid nucleus, and oxidation of the side chain sulphoxide. Identified metabolites are either less active or exhibit similar activity to fulvestrant in antiestrogen models. Studies using human liver preparations and recombinant human enzymes indicate that cytochrome P-450 3A4 (CYP 3A4) is the only P-450 isoenzyme involved in the oxidation of fulvestrant; however, the relative contribution of P-450 and non-P-450 routes in vivo is unknown.
▧ Route of Elimination :
Fulvestrant was rapidly cleared by the hepatobiliary route with excretion primarily via the feces (approximately 90%). Renal elimination was negligible (less than 1%).
▧ Half Life :
40 days
Độc Tính : There is no clinical experience with overdosage in humans.
Chỉ Định : For the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy.
Liều Lượng & Cách Dùng : Solution - Intramuscular
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Faslodex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00947
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01161
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169743
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0310-0720-50
PharmGKB
http://www.pharmgkb.org/drug/PA164747170
Wikipedia
http://en.wikipedia.org/wiki/Fulvestrant
RxList
http://www.rxlist.com/cgi/generic/faslodex.htm
Drugs.com
http://www.drugs.com/cdi/fulvestrant.html
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