Tìm theo
FTY 720
Thuốc Gốc
Small Molecule
CTHH: C19H33NO2
PTK: 307.4708
FTY-720 is an orally active immunosuppressant, under development by Mitsubishi Pharma for use in transplantation and autoimmune diseases. It reduces the number of lymphocytes in the blood by redirecting them to the lymph nodes. FTY-720 is currently in phase II evaluation in a cohort of kidney transplant patients and is expected to enter phase II trials this year with registration filing expected in 2005, with launch in 2006.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H33NO2
Phân tử khối
307.4708
Monoisotopic mass
307.251129305
InChI
InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InChI Key
InChIKey=KKGQTZUTZRNORY-UHFFFAOYSA-N
IUPAC Name
2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
Traditional IUPAC Name
fingolimod
SMILES
CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1
Độ hòa tan
6.90e-03 g/l
logP
4.06
logS
-4.7
pKa (strongest acidic)
14.41
pKa (Strongest Basic)
9.38
PSA
66.48 Å2
Refractivity
93.28 m3·mol-1
Polarizability
38.81 Å3
Rotatable Bond Count
12
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : FTY-720 is an orally active immunosuppressant, under development by Mitsubishi Pharma for use in transplantation and autoimmune diseases. It reduces the number of lymphocytes in the blood by redirecting them to the lymph nodes. FTY-720 is currently in phase II evaluation in a cohort of kidney transplant patients and is expected to enter phase II trials this year with registration filing expected in 2005, with launch in 2006. FTY720 is the first of a new drug class: sphingosine-1-phosphate receptor agonist. Its effect relates to the modulation of lymphocytes trafficking from blood and peripheral tissues to the lymph nodes. Unlike conventional immunosuppressants, FTY720 does not impair the activation, proliferation, or effector functions of T and B cells
Chỉ Định : Investigated for use/treatment in immunosuppressive, multiple sclerosis, and transplant (rejection).
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05286
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=107970
ChemSpider
http://www.chemspider.com/Chemical-Structure.97087.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50158336
Wikipedia
http://en.wikipedia.org/wiki/FTY720
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