Tìm theo
Framycetin
Các tên gọi khác (6 ) :
  • Fradiomycin B
  • Framicetina
  • Framycetin
  • Framycétine
  • Framycetinum
  • Neomycin B
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 119-04-0
ATC: D09AA01, R01AX08, S01AA07
ĐG : Amend
CTHH: C23H46N6O13
PTK: 614.6437
A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H46N6O13
Phân tử khối
614.6437
Monoisotopic mass
614.312285588
InChI
InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChI Key
InChIKey=PGBHMTALBVVCIT-VCIWKGPPSA-N
IUPAC Name
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol
Traditional IUPAC Name
framycetin
SMILES
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
Độ hòa tan
6.47e+01 g/l
logP
-7.8
logS
-0.98
pKa (strongest acidic)
12.29
pKa (Strongest Basic)
9.97
PSA
353.11 Å2
Refractivity
135.9 m3·mol-1
Polarizability
60.87 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
19
H Bond Donor Count
13
Physiological Charge
6
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Framycetin is used for the treatment of bacterial eye infections such as conjunctivitis. Framycetin is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Framycetin works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Framycetin is useful primarily in infections involving aerobic bacteria bacteria.
Cơ Chế Tác Dụng : A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) Framycetin binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Chỉ Định : For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
Liều Lượng & Cách Dùng : Dressing - Topical
Ointment - Ophthalmic
Solution / drops - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Bouchara
    Sản phẩm biệt dược : Isofra
  • Công ty : Bouchara
    Sản phẩm biệt dược : Izofra
  • Công ty : Dermapharm
    Sản phẩm biệt dược : Leukase N
  • Công ty : Royal
    Sản phẩm biệt dược : Pola
  • Công ty : sanofi-aventis
    Sản phẩm biệt dược : Sofra-Tulle
  • Công ty : sanofi-aventis
    Sản phẩm biệt dược : Soframycin
  • Công ty : Melisana
    Sản phẩm biệt dược : Soframycine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00452
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=8378
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508892
ChemSpider
http://www.chemspider.com/Chemical-Structure.8075.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19
PharmGKB
http://www.pharmgkb.org/drug/PA164743181
Wikipedia
http://en.wikipedia.org/wiki/Framycetin
... loading
... loading