Tìm theo
Fosfomycin
Các tên gọi khác (15 ) :
  • (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid
  • (1R,2S)-Epoxypropylphosphonic acid
  • (2R-cis)-(3-Methyloxiranyl)phosphonic acid
  • 1R-cis-(1,2-Epoxypropyl)phosphonic acid
  • cis-(1R,2S)-Epoxypropylphosphonic acid
  • FCM
  • Fosfocina
  • Fosfomicina
  • FOSFOMYCIN
  • Fosfomycine
  • Fosfomycinum
  • L-cis-1,2-Epoxypropylphosphonic acid
  • Phosphomycin
  • Phosphonemycin
  • Phosphonomycin
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 23155-02-4
ATC: J01XX01
ĐG : Forest Pharmaceuticals , http://www.forestpharm.com
CTHH: C3H7O4P
PTK: 138.059
An antibiotic produced by Streptomyces fradiae. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C3H7O4P
Phân tử khối
138.059
Monoisotopic mass
138.008195224
InChI
InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1
InChI Key
InChIKey=YMDXZJFXQJVXBF-STHAYSLISA-N
IUPAC Name
[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
Traditional IUPAC Name
(2R,3S)-3-methyloxiran-2-ylphosphonic acid
SMILES
C[C@@H]1O[C@@H]1P(O)(O)=O
Độ tan chảy
94 °C
Độ hòa tan
50 mg/mL (Sodium salt)
logP
-1.6
logS
-0.47
pKa (strongest acidic)
1.25
pKa (Strongest Basic)
-4.3
PSA
70.06 Å2
Refractivity
25.87 m3·mol-1
Polarizability
10.8 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.
Cơ Chế Tác Dụng : An antibiotic produced by Streptomyces fradiae. [PubChem] Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall.
Dược Động Học :
▧ Absorption :
Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
▧ Volume of Distribution :
* 136.1 ±44.1 L
▧ Protein binding :
0% (not bound to plasma proteins)
▧ Metabolism :
No transformation, excreted unchanged
▧ Route of Elimination :
Fosfomycin is excreted unchanged in both urine and feces.
▧ Half Life :
5.7 (± 2.8) hours. The elimination half-life is 40 hours in anuric patients undergoing hemodialysis.
▧ Clearance :
* 16.9 +/- 3.5 L/hr
Độc Tính : LD50>5 g/kg (rats). Side effects may include diarrhea
Chỉ Định : For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
Liều Lượng & Cách Dùng : Powder - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Viramune 200 mg tablet
    Giá bán buôn : USD >9.48
    Đơn vị tính : tablet
  • Biệt dược thương mại : Monurol 3 gm sachet
    Giá bán buôn : USD >47.07
    Đơn vị tính : each
  • Biệt dược thương mại : Monurol 3 gm Packets
    Giá bán buôn : USD >50.87
    Đơn vị tính : packet
Nhà Sản Xuất
  • Công ty : Forest
    Sản phẩm biệt dược : Monurol
  • Công ty : Roux-Ocefa
    Sản phẩm biệt dược : Veramina
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00828
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=446987
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506665
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06454
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D04253
ChemSpider
http://www.chemspider.com/Chemical-Structure.394204.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0456-4300-08
PharmGKB
http://www.pharmgkb.org/drug/PA164748039
Wikipedia
http://en.wikipedia.org/wiki/Fosfomycin
RxList
http://www.rxlist.com/cgi/generic2/fosfomycin.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/mon1275.shtml
Drugs.com
http://www.drugs.com/cdi/fosfomycin.html
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