Tìm theo
Formebolone
Các tên gọi khác (12 ) :
  • (11a,17b)-11,17-dihydroxy-17-methyl-3-oxo-Androsta-1,4-diene-2-carboxaldehyde
  • 11a,17b-Dihydroxy-17-methyl-3-oxo-Androsta-1,4-diene-2-carboxaldehyde
  • 11a,17b-Dihydroxy-17-methyl-3-oxoandrosta-1,4-diene-2-carboxaldehyde
  • 2-Formyl-11a-hydroxy-D1-methyltestosterone
  • 2-Formyl-17a-methylandrosta-1,4-dien-11a,17b-diol-3-one
  • 2-Formyl-17a-methylandrosta-1,4-diene-11a,17b-dihydroxy-3-one
  • 2-Formyl-17a-methylandrosta-1,4-diene-11a,17b-diol-3-one
  • 219-523-2
  • 2454-11-7
  • Esiclene
  • Formyldienolone
  • Hubernol
steroids
Thuốc Gốc
Small Molecule
CAS: 2454-11-7
CTHH: C21H28O4
PTK: 344.4446
Formebolone, a derivative of androstane [1], is an anabolic androgenic steroid. It is on the list of substances prohibited by the Word Anti-Doping Agency, and is regularly screened for in athletes. It is also classified by the US Drug Enforcement Administration as Schedule III drug in the Controlled Substances Act. It has been used experimentally in the treatment of growth retardation, and has been noted to increase bone mass. [1] Additionally, it has been patented for use in development of novel transdermal delivery systems for enhanced drug delivery.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H28O4
Phân tử khối
344.4446
Monoisotopic mass
344.198759384
InChI
InChI=1S/C21H28O4/c1-19-9-12(11-22)16(23)8-13(19)4-5-14-15-6-7-21(3,25)20(15,2)10-17(24)18(14)19/h8-9,11,14-15,17-18,24-25H,4-7,10H2,1-3H3/t14-,15-,17+,18+,19-,20-,21-/m0/s1
InChI Key
InChIKey=AMVODTGMYSRMNP-GNIMZFFESA-N
IUPAC Name
(1S,2R,10S,11S,14S,15S,17R)-14,17-dihydroxy-2,14,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-4-carbaldehyde
Traditional IUPAC Name
formebolone
SMILES
[H][C@@]12CC[C@](C)(O)[C@@]1(C)C[C@@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C(C=O)=C[C@]12C
Độ tan chảy
210.5 °C
Độ sôi
543.6 °C
Độ hòa tan
6.05e-02 g/l
logP
1.76
logS
-3.8
pKa (strongest acidic)
14.39
pKa (Strongest Basic)
-2.9
PSA
74.6 Å2
Refractivity
96.9 m3·mol-1
Polarizability
38.13 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Chỉ Định : No approve indications. Studied experimentally as a treatment for non-pituitary growth retardation [1].
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01569
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=17150
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508967
ChemSpider
http://www.chemspider.com/Chemical-Structure.16234.html
Wikipedia
http://en.wikipedia.org/wiki/Formebolone
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