Tìm theo
Forasartan
Các tên gọi khác (2) :
  • Forasartan
  • SC-52458
angiotensin receptor antagonists
Thuốc Gốc
Small Molecule
CAS: 145216-43-9
CTHH: C23H28N8
PTK: 416.522
Forasartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H28N8
Phân tử khối
416.522
Monoisotopic mass
416.243692936
InChI
InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)
InChI Key
InChIKey=YONOBYIBNBCDSJ-UHFFFAOYSA-N
IUPAC Name
5-[(dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]pyridine
Traditional IUPAC Name
forasartan
SMILES
CCCCC1=NN(CC2=CN=C(C=C2)C2=CC=CC=C2C2=NNN=N2)C(CCCC)=N1
Độ hòa tan
6.67e-03 g/l
logP
5.89
logS
-4.8
pKa (strongest acidic)
7.35
pKa (Strongest Basic)
3.99
PSA
98.06 Å2
Refractivity
145.44 m3·mol-1
Polarizability
46.79 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
6
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Forasartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. By inhibiting angiotensin II receptors, this drug leads to a decrease in sodium reabsorption (which decreases water content of blood) and a decrease in vasoconstriction. Combined, this has the effect of lowering blood pressure.
Cơ Chế Tác Dụng : Forasartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance. Also, since angiotensin causes vasoconstriction, the inhibition of this receptor decreases vasoconstriction, which consequently also decreases vascular resistnace.
Chỉ Định : For the treatment of hypertension.
Tương Tác Thuốc :
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01342
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=132706
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505698
ChemSpider
http://www.chemspider.com/Chemical-Structure.117146.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049209
PharmGKB
http://www.pharmgkb.org/drug/PA164776845
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