Tìm theo
Follitropin beta
Các tên gọi khác (8 ) :
  • Follicle stimulating hormone beta
  • Follicle-stimulating hormone beta subunit
  • Follitrophin beta
  • Follitropin beta
  • Follitropin beta chain precursor
  • FSH-b
  • FSH-B
  • FSH-beta
fertility agents
Thuốc Gốc
Biotech
CAS: 9002-68-0
ATC: G03GA06
ĐG : EMD Canada Inc. , http://www.emdcanada.com
CTHH: C975H1513N267O304S26
PTK: 22672.9000
Follitropin beta is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C975H1513N267O304S26
Phân tử khối
22672.9000
Độ tan chảy
55 °C
Độ kỵ nước
-0.330
Điểm đẳng điện tích
7.50
Dược Lực Học : Used for the treatment of female infertility, Follitropin beta or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Follitropin beta is the primary hormone responsible for follicular recruitment and development.
Cơ Chế Tác Dụng : Follitropin beta is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH. Follitropin alpha is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
Dược Động Học :
▧ Absorption :
74%
▧ Volume of Distribution :
* 8 L [female subjects following intravenous administration of a 300 IU dose]
▧ Route of Elimination :
Via liver and kidneys
▧ Half Life :
Circulation half life of 3-4 hours, elimination half life of 35-40 hours
▧ Clearance :
* 0.01 1*h-1kg-1 [European women with a single intramuscular dose of 300 IU] * 0.01 1*h-1kg-1 [Japanese women with a single intramuscular dose of 300 IU]
Chỉ Định : For treatment of female infertility
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Intramuscular
Injection, powder, lyophilized, for solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Organon
    Sản phẩm biệt dược : Follistim
  • Sản phẩm biệt dược : Puregon
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00066
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0052-0306-31
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/M16647
PharmGKB
http://www.pharmgkb.org/drug/PA449693
Wikipedia
http://en.wikipedia.org/wiki/Follicle-stimulating_hormone
RxList
http://www.rxlist.com/cgi/generic3/follitrop.htm
Drugs.com
http://www.drugs.com/cdi/follitropin-alfa-powder.html
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