Tìm theo
Folic Acid
Các tên gọi khác (15 ) :
  • Folacin
  • Folate
  • Folic acid
  • Folsaeure
  • N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
  • N-Pteroyl-L-glutamic acid
  • PGA
  • PteGlu
  • Pteroyl-L-glutamate
  • Pteroyl-L-glutamic acid
  • Pteroyl-L-monoglutamic acid
  • Pteroylglutamic acid
  • Vitamin B9
  • Vitamin Bc
  • Vitamin M
Thuốc tác dụng đối với máu
Thuốc Gốc
Small Molecule
CAS: 59-30-3
ĐG : Accucaps Industries Ltd. , http://www.accucaps.com
CTHH: C19H19N7O6
PTK: 441.3975
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H19N7O6
Phân tử khối
441.3975
Monoisotopic mass
441.139681375
InChI
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChI Key
InChIKey=OVBPIULPVIDEAO-LBPRGKRZSA-N
IUPAC Name
(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
Traditional IUPAC Name
folic acid
SMILES
NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1
Độ tan chảy
250 dec °C
Độ hòa tan
1.6 mg/L (at 25 °C)
logP
-2.5
logS
-3.8
pKa (strongest acidic)
3.37
pKa (Strongest Basic)
2.09
PSA
208.99 Å2
Refractivity
111.01 m3·mol-1
Polarizability
42.06 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
12
H Bond Donor Count
6
Physiological Charge
-2
Number of Rings
3
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Folic acid, a water-soluble B-complex vitamin, is found in foods such as liver, kidneys, yeast, and leafy, green vegetables. Folic acid is used to diagnose folate deficiency and to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
Cơ Chế Tác Dụng : A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem] Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
Dược Động Học :

▧ Protein binding :
Very high to plasma protein
▧ Metabolism :
Hepatic
▧ Route of Elimination :
Folic Acid is metabolized in the liver to 7, 8-dihydrofolic acid and eventually to 5,6,7,8-tetrahydrofolic acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Folic Acid is also excreted in the milk of lactating mothers.
Độc Tính : IPR-MUS LD50 85 mg/kg,IVN-GPG LD50 120 mg/kg, IVN-MUS LD50 239 mg/kg, IVN-RAT LD50 500 mg/kg, IVN-RBT LD50 410 mg/kg
Chỉ Định : For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.
Tương Tác Thuốc :
  • Amobarbital Folic acid decreases the effect of anticonvulsant, amobarbital.
  • Aprobarbital Folic acid decreases the effect of anticonvulsant, aprobarbital.
  • Butabarbital Folic acid decreases the effect of anticonvulsant, butabarbital.
  • Butalbital Folic acid decreases the effect of anticonvulsant, butalbital.
  • Butethal Folic acid decreases the effect of anticonvulsant, butethal.
  • Dihydroquinidine barbiturate Folic acid decreases the effect of anticonvulsant, dihydroquinidine barbiturate.
  • Ethotoin Folic acid decreases the levels of hydantoin
  • Fosphenytoin Folic acid decreases the levels of hydantoin
  • Heptabarbital Folic acid decreases the effect of anticonvulsant, heptabarbital.
  • Hexobarbital Folic acid decreases the effect of anticonvulsant, hexobarbital.
  • Mephenytoin Folic acid decreases the levels of hydantoin
  • Methohexital Folic acid decreases the effect of anticonvulsant, methohexital.
  • Methylphenobarbital Folic acid decreases the effect of anticonvulsant, methylphenobarbital.
  • Pentobarbital Folic acid decreases the effect of anticonvulsant, pentobarbital.
  • Phenobarbital Folic acid decreases the effect of anticonvulsant, phenobarbital.
  • Phenytoin Folic acid may decrease the levels of phenytoin.
  • Primidone Folic acid decreases the effect of anticonvulsant, primidone.
  • Quinidine barbiturate Folic acid decreases the effect of anticonvulsant, quinidine barbiturate.
  • Secobarbital Folic acid decreases the effect of anticonvulsant, secobarbital.
  • Talbutal Folic acid decreases the effect of anticonvulsant, talbutal.
Liều Lượng & Cách Dùng : Capsule - Oral
Liquid - Intravenous
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Cazi
    Sản phẩm biệt dược : Acfol
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Fefol
  • Công ty : Meda
    Sản phẩm biệt dược : Folvite
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00158
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6037
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508092
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00504
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00070
ChemSpider
http://www.chemspider.com/Chemical-Structure.5815.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/42291-533-10
PharmGKB
http://www.pharmgkb.org/drug/PA449692
Wikipedia
http://en.wikipedia.org/wiki/Folic_Acid
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/fol_0110.shtml
Drugs.com
http://www.drugs.com/folic_acid.html
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