Tìm theo
Fluorometholone
Các tên gọi khác (10 ) :
  • (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
  • 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
  • Fluor-OP
  • Fluorometholon
  • Fluorométholone
  • Fluorometholone
  • Fluorometholonum
  • Fluorometolona
  • NSC 33001
  • Oxylone
Thuốc dùng điều trị mắt, tai mũi họng
Thuốc Gốc
Small Molecule
CAS: 426-13-1
ATC: C05AA06, D07AB06, D07XB04, D10AA01, S01BA07, S01CB05
ĐG : Alcon Laboratories , http://www.alcon.com
CTHH: C22H29FO4
PTK: 376.4617
A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H29FO4
Phân tử khối
376.4617
Monoisotopic mass
376.204987621
InChI
InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
InChI Key
InChIKey=FAOZLTXFLGPHNG-KNAQIMQKSA-N
IUPAC Name
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Traditional IUPAC Name
fluorometholone
SMILES
[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
Độ tan chảy
292-303
Độ hòa tan
30 mg/L (at 25 °C)
logP
2.00
logS
-4.1
pKa (strongest acidic)
12.65
pKa (Strongest Basic)
-3.4
PSA
74.6 Å2
Refractivity
100.87 m3·mol-1
Polarizability
40.05 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Corticosteroids such as fluorometholone inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
Cơ Chế Tác Dụng : A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732) There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Their primary target is the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.
Độc Tính : Side effects may include acute anterior uveitis and perforation of the globe. Keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation and ptosis have occasionally been reported following local use of corticosteroids. LD50 = 234 mg/kg (rats)
Chỉ Định : For the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
Liều Lượng & Cách Dùng : Solution / drops - Ophthalmic
Suspension - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Allergan
    Sản phẩm biệt dược : Efflumidex
  • Công ty : Alcon
    Sản phẩm biệt dược : Flarex
  • Công ty : Allergan
    Sản phẩm biệt dược : Fluaton
  • Công ty : Ferron
    Sản phẩm biệt dược : Flumetholon
  • Sản phẩm biệt dược : Fluor-op
  • Công ty : Allergan
    Sản phẩm biệt dược : Fluorometholone
  • Công ty : Allergan
    Sản phẩm biệt dược : Flurolon
  • Công ty : Alcon
    Sản phẩm biệt dược : FML
  • Công ty : Allergan
    Sản phẩm biệt dược : FML Forte
  • Công ty : Allergan
    Sản phẩm biệt dược : FML Liquifilm
  • Công ty : Winston
    Sản phẩm biệt dược : Foxone
  • Công ty : Mey See
    Sản phẩm biệt dược : Fucin
  • Công ty : Dae Wo
    Sản phẩm biệt dược : Fuluson
  • Công ty : Han Lim
    Sản phẩm biệt dược : Fumelon
  • Công ty : Kuk Je
    Sản phẩm biệt dược : Humetoron
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00324
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=9878
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505984
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01367
ChemSpider
http://www.chemspider.com/Chemical-Structure.9494.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/11980-228-05
PharmGKB
http://www.pharmgkb.org/drug/PA164781355
Wikipedia
http://en.wikipedia.org/wiki/Fluorometholone
RxList
http://www.rxlist.com/cgi/generic/fluorometholone.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/fml1183.shtml
Drugs.com
http://www.drugs.com/cdi/fluorometholone.html
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