Tìm theo
Fluorescein
Các tên gọi khác (13 ) :
  • 3,6-fluorandiol
  • 3',6'-dihydroxyfluoran
  • 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone
  • 9-(o-carboxyphenyl)-6-hydroxy-3H-xanthen-3-one
  • C.I. Solvent Yellow 94
  • D and C Yellow No. 7
  • D&C Yellow No. 7
  • Fluoresceine
  • Fluoreszein
  • Japan Yellow 201
  • Resorcinolphthalein
  • Solvent Yellow 94
  • Yellow fluorescein
contrast media, fluorescent dyes
Thuốc Gốc
Small Molecule
CAS: 2321-07-5
ATC: S01JA01
ĐG : Accutome Inc. , http://www.accutome.com
CTHH: C20H12O5
PTK: 332.3063
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H12O5
Phân tử khối
332.3063
Monoisotopic mass
332.068473494
InChI
InChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H
InChI Key
InChIKey=GNBHRKFJIUUOQI-UHFFFAOYSA-N
IUPAC Name
3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthene]-3-one
Traditional IUPAC Name
fluorescein
SMILES
OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=CC=C13)C1=C(O2)C=C(O)C=C1
Độ tan chảy
315 dec °C
Độ hòa tan
600 mg/mL (sodium salt)
logP
3.4
logS
-4.1
pKa (strongest acidic)
8.72
pKa (Strongest Basic)
-6
PSA
75.99 Å2
Refractivity
91.22 m3·mol-1
Polarizability
33.14 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
5
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275) Fluorescein sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.
Dược Động Học :
▧ Absorption :
Rapidly distributed
▧ Volume of Distribution :
* 0.5 L/kg
▧ Protein binding :
85%
▧ Route of Elimination :
Fluorescein and its metabolites are mainly eliminated via renal excretion.
▧ Clearance :
* renal cl=1.75 mL/min/kg [After IV administration] * hepatic cl=1.50 mL/min/kg [After IV administration]
Chỉ Định : For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
Liều Lượng & Cách Dùng : Liquid - Intravenous
Liquid - Ophthalmic
Solution - Intravenous
Strip - Ophthalmic
Strip - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : AK-FLUOR
  • Công ty :
    Sản phẩm biệt dược : Fluorescite
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00693
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=16850
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504703
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01261
ChemSpider
http://www.chemspider.com/Chemical-Structure.15968.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0065-0092-65
PharmGKB
http://www.pharmgkb.org/drug/PA164746009
Wikipedia
http://en.wikipedia.org/wiki/Fluorescein
RxList
http://www.rxlist.com/cgi/generic2/fluorescein.htm
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