Tìm theo
Fludiazepam
Các tên gọi khác (3) :
  • 7-chloro-5-(O-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
  • Erispan
  • Fludiazepamum
benzodiazepines
Thuốc Gốc
Small Molecule
CAS: 3900-31-0
CTHH: C16H12ClFN2O
PTK: 302.731
Fludiazepam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a scheduled drug in the U.S., but is approved for use in Japan.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H12ClFN2O
Phân tử khối
302.731
Monoisotopic mass
302.062218928
InChI
InChI=1S/C16H12ClFN2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3
InChI Key
InChIKey=ROYOYTLGDLIGBX-UHFFFAOYSA-N
IUPAC Name
7-chloro-5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Traditional IUPAC Name
fludiazepam
SMILES
CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C1=CC=CC=C1F
Độ tan chảy
218.5-219
Độ hòa tan
1.44e-02 g/l
logP
2.75
logS
-4.3
pKa (Strongest Basic)
1.89
PSA
32.67 Å2
Refractivity
80.03 m3·mol-1
Polarizability
29.45 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Fludiazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Fludiazepam accumulates primarily in the cortex and thalamus.
Cơ Chế Tác Dụng : Fludiazepam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a scheduled drug in the U.S., but is approved for use in Japan. Fludiazepam has similar action to diazepam, but binds with four times more affinity to benzodiazepine receptors than diazepam.
Dược Động Học :

▧ Metabolism :
Hepatic.
Độc Tính : Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death.
Chỉ Định : Used for the short-term treatment of anxiety disorders.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Sumitomo
    Sản phẩm biệt dược : Erispan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01567
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3369
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507563
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01354
ChemSpider
http://www.chemspider.com/Chemical-Structure.3252.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745609
Wikipedia
http://en.wikipedia.org/wiki/Fludiazepam
... loading
... loading