Tìm theo
Flucloxacillin
Các tên gọi khác (8 ) :
  • (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin
  • Floxacillin
  • Floxapen
  • Flucloxacilina
  • Flucloxacillin
  • Flucloxacilline
  • Flucloxacillinum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 5250-39-5
ATC: J01CF05
CTHH: C19H17ClFN3O5S
PTK: 453.872
Antibiotic analog of cloxacillin. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Phân tử khối
453.872
Monoisotopic mass
453.056147271
InChI
InChI=1S/C19H17ClFN3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1
InChI Key
InChIKey=UIOFUWFRIANQPC-JKIFEVAISA-N
IUPAC Name
(2S,5R,6R)-6-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Traditional IUPAC Name
flucloxacillin
SMILES
[H][[email protected]]12SC(C)(C)[[email protected]@H](N1C(=O)[[email protected]]2NC(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl)C(O)=O
Độ hòa tan
5.45e-02 g/l
logP
2.58
logS
-3.9
pKa (strongest acidic)
3.75
pKa (Strongest Basic)
-0.93
PSA
112.74 Å2
Refractivity
106.85 m3·mol-1
Polarizability
41.69 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Cơ Chế Tác Dụng : Antibiotic analog of cloxacillin. [PubChem] By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor.
Dược Động Học :
▧ Absorption :
Bioavailability is 50–70% following oral administration.
▧ Metabolism :
Hepatic.
▧ Half Life :
0.75–1 hour
Chỉ Định : Used to treat bacterial infection by susceptible microorganisms.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Aspen
    Sản phẩm biệt dược : Flopen
  • Công ty : GSK
    Sản phẩm biệt dược : Floxapen
  • Công ty : ACI
    Sản phẩm biệt dược : Fluclox
  • Công ty :
    Sản phẩm biệt dược : Sesamol
  • Công ty :
    Sản phẩm biệt dược : Softapen
  • Công ty : Actavis
    Sản phẩm biệt dược : Staphylex
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