Tìm theo
Flibanserin
Các tên gọi khác (2) :
  • BIMT-17
  • BIMT-17-BS
Thuốc Gốc
Small Molecule
CAS: 167933-07-5
CTHH: C20H21F3N4O
PTK: 390.4021
Flibanserin is a drug produced by Boehringer Ingelheim. It is currently being investigated as a drug for women suffering from decreased sexual desire. It is a 5-HT1A serotonin receptor agonist that had initially been developed as an anti-depressant. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H21F3N4O
Phân tử khối
390.4021
Monoisotopic mass
390.166745929
InChI
InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
InChI Key
InChIKey=PPRRDFIXUUSXRA-UHFFFAOYSA-N
IUPAC Name
1-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
Traditional IUPAC Name
flibanserin
SMILES
FC(F)(F)C1=CC(=CC=C1)N1CCN(CCN2C(=O)NC3=CC=CC=C23)CC1
Độ hòa tan
1.78e-01 g/l
logP
3.83
logS
-3.3
pKa (strongest acidic)
12.91
pKa (Strongest Basic)
7.03
PSA
38.82 Å2
Refractivity
103.65 m3·mol-1
Polarizability
38.69 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Flibanserin is a drug produced by Boehringer Ingelheim. It is currently being investigated as a drug for women suffering from decreased sexual desire. It is a 5-HT1A serotonin receptor agonist that had initially been developed as an anti-depressant. Flibanserin displays antidepressant-like activity in most animal models sensitive to antidepressants. Such activity, however, seems qualitatively different from that exerted by other antidepressants. Flibanserin seems to act via direct or indirect stimulation of 5-HT(1A), DA, and opioid receptors in those animal models.
Cơ Chế Tác Dụng : Flibanserin is a drug produced by Boehringer Ingelheim. It is currently being investigated as a drug for women suffering from decreased sexual desire. It is a 5-HT1A serotonin receptor agonist that had initially been developed as an anti-depressant. [Wikipedia] Flibanserin has preferential affinity for serotonin 5-HT(1A), dopamine D(4k), and serotonin 5-HT(2A) receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5-HT(1A) agonist, a very weak partial agonist on dopamine D(4) receptors, and a 5-HT(2A) antagonist. In vivo flibanserin binds equally to 5-HT(1A) and 5-HT(2A) receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin may occupy 5-HT(2A) receptors in higher proportion than 5-HT(1A) receptors.
Dược Động Học :
▧ Absorption :
Orally available.
Chỉ Định : For the treatment of sexual dysfunction in women.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ectris
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04908
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6918248
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=12014794
ChemSpider
http://www.chemspider.com/Chemical-Structure.5293454.html
Wikipedia
http://en.wikipedia.org/wiki/Flibanserin
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