Tìm theo
Fibrinolysin
Các tên gọi khác (3) :
  • Bovine Fibrinolysin
  • Bovine Plasmin
  • Plasmin
Thuốc Gốc
Biotech
CAS: 9001-90-5
CTHH: C3848H5912N1096O1185S60
PTK: 88411.4
Fibrinolysin (also known as Plasmin) is a bovine enzyme derived from bovine plasma or extracted from bacterial cultures. It is a globular protein with a molecular weight of ~90,000 daltons. Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27,000 Da and contains the active center of fibrinolysin; the heavy chain has a molecular weight of approximately 57,000 Da. Fibrolysin is used as a local healing ointment when combined together with the enzyme deoxyribonuclease I (extracted from bovine pancreas). Fibrinolysin and deoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (Biological Unit) fibrinolysin and 666 BUs desoxyribonuclease per gram. The ointment is marketed by Pfizer under the brand name Fibrolan in a variety of countries is currently not approved in the USA.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C3848H5912N1096O1185S60
Phân tử khối
88411.4
Cơ Chế Tác Dụng : Fibrinolysin (also known as Plasmin) is a bovine enzyme derived from bovine plasma or extracted from bacterial cultures. It is a globular protein with a molecular weight of ~90,000 daltons. Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27,000 Da and contains the active center of fibrinolysin; the heavy chain has a molecular weight of approximately 57,000 Da. Fibrolysin is used as a local healing ointment when combined together with the enzyme deoxyribonuclease I (extracted from bovine pancreas). Fibrinolysin and deoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (Biological Unit) fibrinolysin and 666 BUs desoxyribonuclease per gram. The ointment is marketed by Pfizer under the brand name Fibrolan in a variety of countries is currently not approved in the USA. Fibrinolysin attacks and inactivates fibrin molecules occurring in undesirable exudates on the surface of the human body and on human mucosa, e.g., in superficial wounds and burns, while desoxyribonuclease targets and destroys (human) DNA. The combination of the two enzymes has a synergistic effect on necrotic but not on living tissue.
Dược Động Học :

▧ Metabolism :
local inactivation.
▧ Half Life :
almost completely inactivated after 24 hours.
Chỉ Định : Fibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Pfizer
    Sản phẩm biệt dược : Elase
  • Công ty : Pfizer
    Sản phẩm biệt dược : Fibrolan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08977
Wikipedia
http://en.wikipedia.org/wiki/Fibrinolysin
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