Tìm theo
Fencamfamine
Các tên gọi khác (4 ) :
  • Fencamfamin
  • Fencamfamine
  • Fencamfaminum
  • Fencanfamina
central nervous system stimulants, antipsychotic agents
Thuốc Gốc
Small Molecule
CAS: 1209-98-9
CTHH: C15H21N
PTK: 215.3339
Fencamfamine (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H21N
Phân tử khối
215.3339
Monoisotopic mass
215.167399677
InChI
InChI=1S/C15H21N/c1-2-16-15-13-9-8-12(10-13)14(15)11-6-4-3-5-7-11/h3-7,12-16H,2,8-10H2,1H3
InChI Key
InChIKey=IKFBPFGUINLYQI-UHFFFAOYSA-N
IUPAC Name
N-ethyl-3-phenylbicyclo[2.2.1]heptan-2-amine
Traditional IUPAC Name
fencamfamine
SMILES
CCNC1C2CCC(C2)C1C1=CC=CC=C1
Độ hòa tan
2.95e-03 g/l
logP
3.20
logS
-4.9
pKa (Strongest Basic)
10.56
PSA
12.03 Å2
Refractivity
67.64 m3·mol-1
Polarizability
26.13 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Fencamfamine increases drive and mental alertness and an elevation of mood and a general feeling of well-being. It is a central nervous system stimulant, which increases locomotor activity.
Cơ Chế Tác Dụng : Fencamfamine (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases. [Wikipedia] Fencamfamine acts as an indirect dopamine agonist. It releases dopamine by a similar mechanism to amphetamines, but is 10x less potent than dexamphetamine at producing this effect. The drug seems to inhibit the dopamine transporter (DAT) that removes dopamine from the synapses. This inhibition of DAT blocks the reuptake of dopamine and norepinephrine into the presynaptic neuron, increasing the amount of dopamine in the synapse. It also stimulates the release of dopamine and norepinephrine into the synapse. Finally, it increases the magnitude of dopamine release after a stimulus, increasing the salience of stimulus. Also unlike amphetamines, fencamfamine does not inhibit the action of monoamine oxidase enzymes and so is somewhat safer. Some experiments also suggest a role for opioid receptors in the activity of fencamfamine, as low doses can cause paradoxical sedation, and some effects of the drug are blocked by naloxone.
Độc Tính : Overdosage is characterised by nausea, agitation and restlessness, dryness of the mouth, dizziness and tremor. In gross overdosage the above symptoms may also be associated with dyspnoea, tachycardia, disorientation and convulsions.
Chỉ Định : For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy.
Liều Lượng & Cách Dùng : Syrup - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Glucoenergan
  • Công ty :
    Sản phẩm biệt dược : Reactivan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01463
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=14584
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508161
ChemSpider
http://www.chemspider.com/Chemical-Structure.13922.html
PharmGKB
http://www.pharmgkb.org/drug/PA164747055
Wikipedia
http://en.wikipedia.org/wiki/Fencamfamine
... loading
... loading