Tìm theo
Fenbufen
Các tên gọi khác (6 ) :
  • 3-(4-Biphenylylcarbonyl)propionic acid
  • 3-(4-Phenylbenzoyl)propionic acid
  • 4-(4-Biphenylyl)-4-oxobutyric acid
  • 4-Biphenyl-4-yl-4-oxobutanoic acid
  • Fenbufen
  • gamma-oxo(1,1'-Biphenyl)-4-butanoic acid
Thuốc Gốc
Small Molecule
CAS: 36330-85-5
CTHH: C16H14O3
PTK: 254.2806
Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H14O3
Phân tử khối
254.2806
Monoisotopic mass
254.094294314
InChI
InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)
InChI Key
InChIKey=ZPAKPRAICRBAOD-UHFFFAOYSA-N
IUPAC Name
4-oxo-4-(4-phenylphenyl)butanoic acid
Traditional IUPAC Name
fenbufen
SMILES
OC(=O)CCC(=O)C1=CC=C(C=C1)C1=CC=CC=C1
Độ tan chảy
185-187
Độ hòa tan
1.21e-02 g/l
logP
3
logS
-4.3
pKa (strongest acidic)
4.22
pKa (Strongest Basic)
-7.5
PSA
54.37 Å2
Refractivity
72.49 m3·mol-1
Polarizability
27.47 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08981
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01344
Wikipedia
http://en.wikipedia.org/wiki/Fenbufen
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