Tìm theo
Famciclovir
Các tên gọi khác (8 ) :
  • 2-(2-(2-amino-9H-Purin-9-yl)ethyl)-1,3-propanediol diacetate
  • 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine
  • Acetic acid 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester
  • BRL-42810
  • Famciclovir
  • Famciclovirum
  • Famvir
  • FCV
antiviral agents, prodrugs, nucleic acids nucleotides and nucleosides
Thuốc Gốc
Small Molecule
CAS: 104227-87-4
ATC: J05AB09, S01AD07
ĐG : Apotheca Inc.
CTHH: C14H19N5O4
PTK: 321.3318
Famciclovir is a guanine analogue antiviral drug used for the treatment of various herpes virus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H19N5O4
Phân tử khối
321.3318
Monoisotopic mass
321.143704121
InChI
InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
InChI Key
InChIKey=GGXKWVWZWMLJEH-UHFFFAOYSA-N
IUPAC Name
2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
Traditional IUPAC Name
famciclovir
SMILES
CC(=O)OCC(CCN1C=NC2=CN=C(N)N=C12)COC(C)=O
Độ tan chảy
102-104 °C
Độ hòa tan
1.32e+00 g/l
logP
0.6
logS
-2.4
pKa (strongest acidic)
16.7
pKa (Strongest Basic)
5.05
PSA
122.22 Å2
Refractivity
81.54 m3·mol-1
Polarizability
32.83 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
6
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Famciclovir is a prodrug that undergoes rapid biotransformation to the active antiviral compound penciclovir. Penciclovir is an anti-viral drug which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). Therefore, herpes viral DNA synthesis and replication are selectively inhibited.
Cơ Chế Tác Dụng : Famciclovir is a guanine analogue antiviral drug used for the treatment of various herpes virus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis). Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases. In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.
Dược Động Học :
▧ Absorption :
77 %
▧ Volume of Distribution :
* 1.08±0.17 L/kg [healthy male subjects following a single intravenous dose of penciclovir at 400 mg administered as a 1-hour intravenous infusion]
▧ Protein binding :
20-25%
▧ Metabolism :
Hepatic
▧ Route of Elimination :
Active tubular secretion contributes to the renal elimination of penciclovir.
▧ Half Life :
10 hours
▧ Clearance :
* 36.6 +/- 6.3 L/hr [healthy male] * 0.48 +/- 0.09 L/hr/kg [healthy male]
Độc Tính : Symptoms of overdose include constipation, diarrhea, dizziness, fatigue, fever, headache, nausea, and vomiting.
Chỉ Định : For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Alphapharm
    Sản phẩm biệt dược : Ezovir
  • Công ty : Il Hwa
    Sản phẩm biệt dược : Fambir
  • Công ty : Daewoong
    Sản phẩm biệt dược : Famcino
  • Công ty : Kwang Dong
    Sản phẩm biệt dược : Famcir
  • Công ty : Novartis
    Sản phẩm biệt dược : Famvir
  • Công ty : Novartis
    Sản phẩm biệt dược : Famvir Once
  • Công ty : Blausiegel
    Sản phẩm biệt dược : Fanclomax
  • Công ty : Jialin
    Sản phẩm biệt dược : Fanle
  • Công ty : Micro Gratia
    Sản phẩm biệt dược : Microvir
  • Công ty : Novartis
    Sản phẩm biệt dược : Oravir
  • Công ty : Fortbenton
    Sản phẩm biệt dược : Pentavir
  • Công ty : Hetero
    Sản phẩm biệt dược : Penvir
  • Sản phẩm biệt dược : Pixin
  • Công ty : FDC
    Sản phẩm biệt dược : Virovir
  • Sản phẩm biệt dược : Wan Qi
  • Công ty : Hisun
    Sản phẩm biệt dược : Weike
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00426
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3324
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507561
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00317
ChemSpider
http://www.chemspider.com/Chemical-Structure.3207.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066502
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0078-0366-15
PharmGKB
http://www.pharmgkb.org/drug/PA449585
Wikipedia
http://en.wikipedia.org/wiki/Famciclovir
RxList
http://www.rxlist.com/cgi/generic3/famciclovir.htm
Drugs.com
http://www.drugs.com/cdi/famciclovir.html
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