Tìm theo
Etorphine
Các tên gọi khác (1) :
  • Etorphinum
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 14521-96-1
CTHH: C25H33NO4
PTK: 411.5338
A narcotic analgesic morphinan used as a sedative in veterinary practice. In Hong Kong, Etorphine is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. In the US, Etorphine is listed as a Schedule I drug, although Etorphine hydrochloride is classified as Schedule II.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C25H33NO4
Phân tử khối
411.5338
Monoisotopic mass
411.240958549
InChI
InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17?,18-,21?,22?,23-,24+,25?/m1/s1
InChI Key
InChIKey=CAHCBJPUTCKATP-HBDRVVKHSA-N
IUPAC Name
(1R,2R,6S)-19-(2-hydroxypentan-2-yl)-15-methoxy-3-methyl-13-oxa-3-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{6,14}.0^{7,12}]icosa-7,9,11,16-tetraen-11-ol
Traditional IUPAC Name
(1R,2R,6S)-19-(2-hydroxypentan-2-yl)-15-methoxy-3-methyl-13-oxa-3-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{6,14}.0^{7,12}]icosa-7,9,11,16-tetraen-11-ol
SMILES
[H][C@]12CC3=C4C(OC5[C@@]4(CCN1C)[C@]21CC(C(C)(O)CCC)C5(OC)C=C1)=C(O)C=C3
Độ tan chảy
214-217 °C
Độ hòa tan
1.12e-01 g/l
logP
2.79
logS
-3.6
pKa (strongest acidic)
7.48
pKa (Strongest Basic)
11.72
PSA
62.16 Å2
Refractivity
116.51 m3·mol-1
Polarizability
45.55 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
6
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Etorphine is a synthetic cousin of morphine and 40,000 times more powerful. It can be produced from thebaine. It is most often used to immobilize elephants and other large mammals. Etorphine is only available legally for veterinary use and is strictly governed by law.
Cơ Chế Tác Dụng : A narcotic analgesic morphinan used as a sedative in veterinary practice. In Hong Kong, Etorphine is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. In the US, Etorphine is listed as a Schedule I drug, although Etorphine hydrochloride is classified as Schedule II. Etorphine is an agonist at mu, delta, and kappa opioid receptors. It also has a weak affinity for the ORL1 nociceptin/orphanin FQ receptor.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01497
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=26721
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505591
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11793
ChemSpider
http://www.chemspider.com/Chemical-Structure.24895.html
Wikipedia
http://en.wikipedia.org/wiki/Etorphine
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