Tìm theo
Etomidate
Các tên gọi khác (10 ) :
  • (+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate
  • (+)-ethyl 1-(α-methylbenzyl)imidazole-5-carboxylate
  • (+)-etomidate
  • (R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester
  • (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
  • 3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester
  • Etomidate
  • Etomidato
  • Etomidatum
  • R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
Thuốc gây tê, mê
Thuốc Gốc
Small Molecule
CAS: 33125-97-2
ATC: N01AX07
ĐG : American Regent , http://www.americanregent.com
CTHH: C14H16N2O2
PTK: 244.289
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H16N2O2
Phân tử khối
244.289
Monoisotopic mass
244.121177766
InChI
InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
InChI Key
InChIKey=NPUKDXXFDDZOKR-LLVKDONJSA-N
IUPAC Name
ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate
Traditional IUPAC Name
ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate
SMILES
CCOC(=O)C1=CN=CN1[C@H](C)C1=CC=CC=C1
Độ tan chảy
142-142.8
Độ hòa tan
63.2 mg/L
logP
3.05
logS
-2.7
pKa (Strongest Basic)
4.54
PSA
44.12 Å2
Refractivity
69.59 m3·mol-1
Polarizability
26.43 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Etomidate is a non-barbiturate hypnotic that acts at the level of the reticular-activating system to produce anesthesia. Etomidate is an imidazole compound that appears to depress CNS function via GABA. Duration of action is intermediate between thiopental and methohexital, and recovery from a single dose is rapid with little residual depression. Like the barbiturates and propofol, etomidate is does not induce analgesia. Etomidate induces unconsciousness within one circulation time. Recovery is rapid as a result of extensive redistribution and rapid metabolism.
Cơ Chế Tác Dụng : Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic. [PubChem] Etomidate binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Dược Động Học :

▧ Protein binding :
76%, primarily to serum albumin.
▧ Metabolism :
Hepatic. Metabolized rapidly by ester hydrolysis to inactive metabolites.
▧ Route of Elimination :
Approximately 75% of the administered dose is excreted in the urine during the first day after injection.
▧ Half Life :
75 minutes.
Độc Tính : Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.
Chỉ Định : Used in the induction of general anesthesia.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Hospira
    Sản phẩm biệt dược : Amidate
  • Công ty : Bedford
    Sản phẩm biệt dược : Etomidate
  • Công ty : Janssen
    Sản phẩm biệt dược : Hypnomidate
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00292
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07522
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00548
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50125938
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0409-6695-01
PharmGKB
http://www.pharmgkb.org/drug/PA164743987
Wikipedia
http://en.wikipedia.org/wiki/Etomidate
Drugs.com
http://www.drugs.com/cdi/etomidate.html
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