Tìm theo
Etifoxine
Thuốc điều trị về tâm thần
Thuốc Gốc
Small Molecule
CAS: 21715-46-8
CTHH: C17H18Cl2N2O
PTK: 337.244
Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It has similar effects to benzodiazepine drugs, but is structurally distinct and does not bind to the benzodiazepine receptor. It is more effective than lorazepam as an anxiolytic, and has fewer side effects. Etifoxine has been associated with acute liver injury.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H18Cl2N2O
Phân tử khối
337.244
Monoisotopic mass
336.079618622
InChI
InChI=1/C17H17ClN2O.ClH/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12;/h4-11H,3H2,1-2H3,(H,19,20);1H
InChI Key
InChIKey=SCBJXEBIMVRTJE-UHFFFAOYNA-N
IUPAC Name
6-chloro-N-ethyl-4-methyl-4-phenyl-2,4-dihydro-1H-3,1-benzoxazin-2-imine hydrochloride
Traditional IUPAC Name
etifoxine hydrochloride
SMILES
Cl.CCN=C1NC2=C(C=C(Cl)C=C2)C(C)(O1)C1=CC=CC=C1
Độ tan chảy
90-92
Độ hòa tan
2.28e-03 g/l
logP
4.67
logS
-5.1
pKa (Strongest Basic)
4.87
PSA
33.62 Å2
Refractivity
87 m3·mol-1
Polarizability
32.24 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Euroetika
    Sản phẩm biệt dược : Exsist
  • Công ty : Biocodex
    Sản phẩm biệt dược : Stresam
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08986
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07320
Wikipedia
http://en.wikipedia.org/wiki/Etifoxine
Drugs.com
http://www.drugs.com/international/etifoxine.html
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