Tìm theo
Ethinamate
Các tên gọi khác (5 ) :
  • 1-Ethynylcyclohexanol carbamate
  • Aethinyl-cyclohexyl-carbamat
  • Ethinamate
  • Ethinamatum
  • Etinamato
Thuốc Gốc
Small Molecule
CAS: 126-52-3
CTHH: C9H13NO2
PTK: 167.205
Ethinamate is a short-acting sedative-hypnotic medication used to treat insomnia. Regular use leads to tolerance, and it is usually not effective for more than 7 days. Structurally, it does not resemble the barbituates, but it shares many effects with this class of drugs; the depressant effects of ethinamate are, however, generally milder than those of most barbiturates.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H13NO2
Phân tử khối
167.205
Monoisotopic mass
167.094628665
InChI
InChI=1S/C9H13NO2/c1-2-9(12-8(10)11)6-4-3-5-7-9/h1H,3-7H2,(H2,10,11)
InChI Key
InChIKey=GXRZIMHKGDIBEW-UHFFFAOYSA-N
IUPAC Name
1-ethynylcyclohexyl carbamate
Traditional IUPAC Name
ethinamate
SMILES
NC(=O)OC1(CCCCC1)C#C
Độ tan chảy
94-96
Độ sôi
120 °C at 3.00E+00 mm Hg
Độ hòa tan
2500 mg/L (at 25 °C)
logP
1.2
logS
-3.2
pKa (strongest acidic)
15.37
PSA
52.32 Å2
Refractivity
44.57 m3·mol-1
Polarizability
17.73 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Ethinamate is used to treat insomnia (trouble in sleeping). However, it has generally been replaced by other medicines for the treatment of insomnia. If ethinamate is used regularly (for example, every day) to help produce sleep, it is usually not effective for more than 7 days. Structurally, it does not resemble the barbiturates, but it shares many effects with this class of drugs; the depressant effects of ethinamate are, however, generally milder than those of most barbiturates. Continued and inappropriate use of ethinamate can lead to tolerance and physical dependence, with withdrawal symptoms very similar to those of the barbiturates.
Cơ Chế Tác Dụng : Ethinamate is a short-acting sedative-hypnotic medication used to treat insomnia. Regular use leads to tolerance, and it is usually not effective for more than 7 days. Structurally, it does not resemble the barbituates, but it shares many effects with this class of drugs; the depressant effects of ethinamate are, however, generally milder than those of most barbiturates. The mechanism of action is not known. However, studies have shown that ethinamate inhibits carbonic anhydrases I and II (J Biol Chem. 1992 Dec 15;267(35):25044-50). This inhibition by ethinamate is not sufficiently strong, however, to implicate carbonic anhydrases I and II in the mechanism of action.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration.
▧ Metabolism :
Hepatic.
▧ Half Life :
2.5 hours
Độc Tính : Symptoms of overdose include shortness of breath or slow or troubled breathing, slow heartbeat, severe weakness, chronic confusion, slurred speech, and staggering.
Chỉ Định : Used for the short-term treatment of insomnia, however, it generally has been replaced by other sedative-hypnotic agents.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Schering
    Sản phẩm biệt dược : Valamin
  • Công ty : Dista
    Sản phẩm biệt dược : Valmid
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01031
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3284
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507468
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07832
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00703
ChemSpider
http://www.chemspider.com/Chemical-Structure.3169.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745394
Wikipedia
http://en.wikipedia.org/wiki/Ethinamate
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