Tìm theo
Ethanolamine Oleate
Các tên gọi khác (5 ) :
  • beta-Hydroxyethylammonium oleate
  • Ethamolin
  • Ethanolamine oleate
  • Monoethanolamine oleate
  • Oldamin
sclerosing solutions
Thuốc Gốc
Small Molecule
CAS: 2272-11-9
ATC: C05BB01
ĐG : Ben Venue Laboratories Inc. , http://www.benvenue.com
CTHH: C20H41NO3
PTK: 343.5444
Ethanolamine Oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H41NO3
Phân tử khối
343.5444
Monoisotopic mass
343.308644183
InChI
InChI=1S/C18H34O2.C2H7NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;3-1-2-4/h9-10H,2-8,11-17H2,1H3,(H,19,20);4H,1-3H2/b10-9-;
InChI Key
InChIKey=KGWDUNBJIMUFAP-KVVVOXFISA-N
IUPAC Name
(9Z)-octadec-9-enoic acid; 2-aminoethan-1-ol
Traditional IUPAC Name
ethanolamine; oleic acid
SMILES
NCCO.CCCCCCCC\C=C/CCCCCCCC(O)=O
logP
6.78
pKa (strongest acidic)
4.99
PSA
37.3 Å2
Refractivity
87.4 m3·mol-1
Polarizability
37.09 Å3
Rotatable Bond Count
16
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
0
Bioavailability
0
Dược Lực Học : When injected intravenously, ethanolamine oleate acts primarily by irritation of the intimal endothelium of the vein and produces a sterile dose-related inflammatory response. This results in fibrosis and possible occlusion of the vein. Ethanolamine oleate also rapidly diffuses through the venous wall and produces a dose-related extravascular inflammatory reaction.
Cơ Chế Tác Dụng : Ethanolamine Oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate. The oleic acid component of ethanolamine oleate is responsible for the inflammatory response, and may also activate coagulation in vivo by release of tissue factor and activation of Hageman factor. The ethanolamine component, however, may inhibit fibrin clot formation by chelating calcium, so that a procoagulant action of ethanolamine oleate has not been demonstrated.
Dược Động Học :
▧ Absorption :
After injection into an esophageal varix, ethanolamine oleate is cleared from the injection site within five minutes via the portal vein. Some of the medication also flows into the azygos vein through the periesophageal vein if more than 20 mL is injected.
Độc Tính : The minimum lethal dose administered intravenously to rabbits is 130 mg/kg. Overdosage can result in severe intramural necrosis of the esophagus. Complications resulting from such overdosage have resulted in death. LD50 (intravenous) in rats is 156 mg/kg. LD50 (intravenous) in dogs is 175 mg/kg.
Chỉ Định : For the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding.
Liều Lượng & Cách Dùng : Solution - Intravenous - 5%
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Ethamolin 5% ampul
    Giá bán buôn : USD >86.62
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ethamolin
  • Công ty :
    Sản phẩm biệt dược : Monolate
  • Công ty :
    Sản phẩm biệt dược : Moramin
  • Công ty :
    Sản phẩm biệt dược : Neosclerol
  • Công ty :
    Sản phẩm biệt dược : Oldamin
  • Công ty :
    Sản phẩm biệt dược : Varicetin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06689
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5282489
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443246
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02276
ChemSpider
http://www.chemspider.com/Chemical-Structure.4445632.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/67871-479-06
PharmGKB
http://www.pharmgkb.org/drug/PA164746758
Wikipedia
http://en.wikipedia.org/wiki/Monoethanolamine_oleate
RxList
http://www.rxlist.com/cgi/generic/ethamolin.htm
Drugs.com
http://www.drugs.com/mtm/ethanolamine-oleate.html
... loading
... loading