Tìm theo
Estriol
Các tên gọi khác (12 ) :
  • (16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol
  • (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol
  • 1,3,5(10)-Estratriene-3,16-alpha,17beta-triol
  • 16-alpha-Hydroxyestradiol
  • 16alpha-hydroxyestradiol
  • 16α-hydroxyestradiol
  • 3,16alpha,17beta-Trihydroxy-delta(1,3,5)-estratriene
  • Deuslon-a
  • Estriel
  • Estriol
  • Oestriol
  • Trihydroxyestrin
Hormon, Nội tiết tố
Thuốc Gốc
Small Molecule
CAS: 50-27-1
ATC: G03CC06, G03CA04
ĐG : Jiangxi Yuneng Pharmchem Co. Ltd. , http://www.yunengchem.com
CTHH: C18H24O3
PTK: 288.3814
A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H24O3
Phân tử khối
288.3814
Monoisotopic mass
288.172544634
InChI
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
InChI Key
InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N
IUPAC Name
(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol
Traditional IUPAC Name
estriol
SMILES
[H][C@@]12C[C@@H](O)[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
Độ tan chảy
82-86
Độ hòa tan
1.19e-01 g/l
logP
2.45
logS
-3.4
pKa (strongest acidic)
10.33
pKa (Strongest Basic)
-3.2
PSA
60.69 Å2
Refractivity
81.27 m3·mol-1
Polarizability
33.07 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
Cơ Chế Tác Dụng : A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. The drug interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estriol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
Độc Tính : ORAL (LD50): Acute: >2000 mg/kg [Rat].
Chỉ Định : Used as a test to determine the general health of an unborn fetus.
Tương Tác Thuốc :
  • Fosphenytoin The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, estriol.
  • Griseofulvin The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, estriol.
  • Phenobarbital The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, estriol.
  • Phenytoin The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estriol.
  • Prednisolone The estrogenic agent, estriol, may increase the effect of the corticosteroid, prednisolone.
  • Prednisone The estrogenic agent, estriol, may increase the effect of corticosteroid, prednisone.
  • Primidone The enzyme inducer, primidone, decreases the effect of the hormone agent, estriol.
  • Raloxifene Association not recommended
Liều Lượng & Cách Dùng : Cream - Intravaginal - 0.5mg
Cream - Intravaginal - 1.0mg
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Organon
    Sản phẩm biệt dược : Aacifemine
  • Công ty : Temis-Lostalo
    Sản phẩm biệt dược : Colpoestriol
  • Sản phẩm biệt dược : Ovestin
  • Công ty : Organon
    Sản phẩm biệt dược : Synapause E
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04573
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5756
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505881
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C05141
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00185
ChemSpider
http://www.chemspider.com/Chemical-Structure.5553.html
PharmGKB
http://www.pharmgkb.org/drug/PA164769104
Wikipedia
http://en.wikipedia.org/wiki/Estriol
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