Tìm theo
Erythrityl Tetranitrate
Các tên gọi khác (12 ) :
  • (2R*,3S)-rel-1,2,3,4-butanetetroltetranitrate
  • 1,2,3,4-Butanetetralyl tetranitrate
  • Eritrityl tetranitrate
  • Eritrityli tetranitras
  • Erythritol tetranitrate
  • Erythrol tetranitrate
  • ETN
  • Meso-erythritol tetranitrate
  • Tetranitrate d'eritrityle
  • Tetranitrato de eritritilo
  • Tetranitrin
  • Tetranitrol
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 7297-25-8
ATC: C01DA13
CTHH: C4H6N4O12
PTK: 302.11
A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C4H6N4O12
Phân tử khối
302.11
Monoisotopic mass
301.998221676
InChI
InChI=1S/C4H6N4O12/c9-5(10)17-1-3(19-7(13)14)4(20-8(15)16)2-18-6(11)12/h3-4H,1-2H2/t3-,4+
InChI Key
InChIKey=SNFOERUNNSHUGP-ZXZARUISSA-N
IUPAC Name
(2S,3R)-2,3,4-tris(nitrooxy)butyl nitrate
Traditional IUPAC Name
erythrityl tetranitrate
SMILES
[O-][N+](=O)OC[C@@H](O[N+]([O-])=O)[C@H](CO[N+]([O-])=O)O[N+]([O-])=O
Độ tan chảy
61 °C
Độ hòa tan
1.95e-01 g/l
logP
1.23
logS
-3.2
pKa (Strongest Basic)
-5.5
PSA
220.2 Å2
Refractivity
53.25 m3·mol-1
Polarizability
20.27 Å3
Rotatable Bond Count
11
H Bond Acceptor Count
12
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
0
Ghose Filter
true
Dược Lực Học : Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin.
Cơ Chế Tác Dụng : A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020) Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Độc Tính : Symptoms of overdose include increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
Chỉ Định : For the prevention of angina.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cardilate
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01613
PharmGKB
http://www.pharmgkb.org/drug/PA164746528
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