Tìm theo
Epoetin Zeta
Các tên gọi khác (5 ) :
  • 1-165-Erythropoietin (human clone B03XA01) glycoform zeta
  • Epoetin zeta
  • Epoetina dseta
  • Epoétine zêta
  • Epoetinum zeta
Thuốc Gốc
Biotech
CAS: 604802-70-2
CTHH: C809H1301N229O240S5
PTK: 18200
The active substance in Epoetin zeta is a recombinant human erythropoietin (rhEPO) of identical primary structure produced in Chinese Hamster Ovary (CHO) cells. The molecular weight of the glycosylated protein is 30.6 kDa according to the Ph. Eur. monograph, 40% of which are carbohydrate structures. The oligosaccharide chains are subject to posttranslational modifications and display heterogeneity to a certain extent. Epoetin zeta is also identical to Epoetin alfa in terms of its amino acid sequence.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C809H1301N229O240S5
Phân tử khối
18200
Dược Lực Học : Used in the treatment of anemia. Involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Cơ Chế Tác Dụng : The active substance in Epoetin zeta is a recombinant human erythropoietin (rhEPO) of identical primary structure produced in Chinese Hamster Ovary (CHO) cells. The molecular weight of the glycosylated protein is 30.6 kDa according to the Ph. Eur. monograph, 40% of which are carbohydrate structures. The oligosaccharide chains are subject to posttranslational modifications and display heterogeneity to a certain extent. Epoetin zeta is also identical to Epoetin alfa in terms of its amino acid sequence. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Dược Động Học :

▧ Half Life :
Toxicokinetic results from rats in a 13 week toxicity study after a single subcutaneous dose: 7.37 hours (+/- 0.70) with 500 IU/kg [test 1] 8.63 hours (+/- 2.78) with 2500 IU/kg [test 2] 8.76 hours (+/- 1.46) with 2500 IU/kg [reference dose]
Chỉ Định : For use in the treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric patients. Also for use in the treatment of anaemia and reduction of transfusion requirements in adult patients receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient's general status (e.g. cardiovascular status, pre-existing anaemia at the start of chemotherapy). Also for used to increase the yield of autologous blood from patients in a predonation program. When administered subcutaneously, Epoetin Zeta is equivalent to Epoetin Alfa in terms of clinical effectiveness.
Liều Lượng & Cách Dùng : Solution - Intravenous - 40,000 IU/ml
Solution - Intravenous - 10,000 IU/ml
Solution - Intravenous - 3,333 IU/ml
Solution - Subcutaneous - 40,000 IU/ml
Solution - Subcutaneous - 10,000 IU/ml
Solution - Subcutaneous - 3,333 IU/ml
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08923
Wikipedia
http://en.wikipedia.org/wiki/Erythropoietin
Drugs.com
http://www.drugs.com/international/epoetin-zeta.html
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