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Epoetin alfa
Các tên gọi khác (1) :
  • Erythropoietin precursor
Thuốc tác dụng đối với máu
Thuốc Gốc
Biotech
CAS: 113427-24-0
ATC: B03XA01
ĐG : Amgen Inc. , http://www.amgen.com
CTHH: C815H1317N233O241S5
PTK: 18396.1000
Human erythropoietin (recombinant), produced by CHO cells.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C815H1317N233O241S5
Phân tử khối
18396.1000
Độ tan chảy
53 °C
Điểm đẳng điện tích
8.75
Dược Lực Học : Used in the treatment of anemia. Involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Cơ Chế Tác Dụng : Human erythropoietin (recombinant), produced by CHO cells. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Dược Động Học :

▧ Clearance :
* 20.2 +/- 15.9 mL/h/kg [150 Units/kg SC TIW, Week 1 when anemic cancer patients were receiving chemotherapy] * 23.6 +/- 9.5 mL/h/kg [150 Units/kg SC TIW, Week 3 when anemic cancer patients were not receiving chemotherapy] * 9.2 +/- 4.7 mL/h/kg [40,000 Units/kg SC TIW, Week 1 when anemic cancer patients were receiving chemotherapy] * 13.9 +/- 7.6 mL/h/kg [40,000 Units/kg SC TIW, Week 3 when anemic cancer patients were not receiving chemotherapy]
Chỉ Định : For treatment of anemia (from renal transplants or certain HIV treatment)
Liều Lượng & Cách Dùng : Liquid - Subcutaneous
Solution - Intravenous
Solution - Subcutaneous
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