Tìm theo
Enprofylline
Các tên gọi khác (7 ) :
  • 3-n-Propylxanthine
  • 3-Propyl-3,7-dihydro-purine-2,6-dione
  • 3-Propylxanthine
  • 3,7-dihydro-3-Propyl-1H-purine-2,6-dione
  • Enprofilina
  • Enprofylline
  • Enprofyllinum
anti asthmatic agents, anti arrhythmia agents, bronchodilator agents, adenosine a2 receptor antagonists
Thuốc Gốc
Small Molecule
CAS: 41078-02-8
CTHH: C8H10N4O2
PTK: 194.1906
Enprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Long-term enprofylline administration may be associated with elevation in liver enzyme levels and unpredictable blood levels.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H10N4O2
Phân tử khối
194.1906
Monoisotopic mass
194.080375584
InChI
InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)
InChI Key
InChIKey=SIQPXVQCUCHWDI-UHFFFAOYSA-N
IUPAC Name
3-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Traditional IUPAC Name
enprofylline
SMILES
CCCN1C2=C(NC=N2)C(=O)NC1=O
Độ tan chảy
287-289 °C
Độ hòa tan
1200 mg/L
logP
0.33
logS
-1.5
pKa (strongest acidic)
7.83
pKa (Strongest Basic)
-0.77
PSA
78.09 Å2
Refractivity
49.31 m3·mol-1
Polarizability
18.72 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Enprofylline is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.
Cơ Chế Tác Dụng : Enprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Long-term enprofylline administration may be associated with elevation in liver enzyme levels and unpredictable blood levels. Enprofylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
Dược Động Học :
▧ Absorption :
Rapidly absorbed from the digestive tract
▧ Protein binding :
49%
▧ Half Life :
1.9 hours
Chỉ Định : Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Nilyph
  • Công ty :
    Sản phẩm biệt dược : Oxeze
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00824
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=1676
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505790
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D04006
ChemSpider
http://www.chemspider.com/Chemical-Structure.1613.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001493
PharmGKB
http://www.pharmgkb.org/drug/PA164749350
Wikipedia
http://en.wikipedia.org/wiki/Enprofylline
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