Dược Động Học :
▧ Absorption :
After a 90 mg single subcutaneous injection of Enfuvirtide into the abdomen in 12 HIV-1 infected subjects, the mean peak concentration is 4.59+/-1.5 ug/ml and the median time to peak concentration was 8 hours (ranged from 3 to12 hours).
▧ Volume of Distribution :
* 5.5 ± 1.1 L
▧ Protein binding :
▧ Metabolism :
Expected to undergo catabolism to its constituent amino acids, with subsequent recycling of the amino acids in the body pool.
▧ Half Life :
3.8 +/- 0.6 hrs
▧ Clearance :
* 24.8 +/- 4.1 mL/h/kg [HIV-1 infected adult and pediatric subjects following a 90-mg single SC dose of enfuvirtide]
* 30.6 +/- 10.6 mL/h/kg [Following 90-mg twice daily dosing of FUZEON SC in combination with other antiretroviral agents in HIV-1 infected subjects]
* 40 +/- 17 mL/h/kg [pediatric patients in the presence of concomitant medications including antiretroviral agents receiving the 2 mg/kg twice daily dose]