Tìm theo
Encainide
Các tên gọi khác (7 ) :
  • (+-)-2'-[2-(1-Methyl-2-piperidyl)ethyl]-P-anisanilide
  • (+-)-4-Methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide
  • 4-Methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
  • 4-Methoxy-N-{2-[2-(1-methyl-piperidin-2-yl)-ethyl]-phenyl}-benzamide
  • Encainida
  • Encainide
  • Encainidum
Thuốc chống loạn nhịp
Thuốc Gốc
Small Molecule
CAS: 66778-36-7
ATC: C01BC08
ĐG : Bristol-Myers Squibb Co. , http://www.bms.com
CTHH: C22H28N2O2
PTK: 352.4699
All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H28N2O2
Phân tử khối
352.4699
Monoisotopic mass
352.21507815
InChI
InChI=1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25)
InChI Key
InChIKey=PJWPNDMDCLXCOM-UHFFFAOYSA-N
IUPAC Name
4-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide
Traditional IUPAC Name
encainide
SMILES
COC1=CC=C(C=C1)C(=O)NC1=CC=CC=C1CCC1CCCCN1C
Độ hòa tan
4.01e-03 g/l
logP
4
logS
-4.9
pKa (strongest acidic)
12.37
pKa (Strongest Basic)
9.48
PSA
41.57 Å2
Refractivity
107.77 m3·mol-1
Polarizability
41.04 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Used to treat irregular heartbeats, encainide decreases excitability, conduction velocity, and automaticity as a result of slowed atrial, atrioventricular (AV) nodal, His-Purkinje, and intraventricular conduction. It causes a slight but significant prolongation of refractory periods in these tissues. The greatest effect is on the His-Purkinje system. Encainide decreases the rate of rise of the action potential without markedly affecting its duration.
Cơ Chế Tác Dụng : All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991. Encainide is a sodium channel blocker, binding to voltage gated sodium channels. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole.
Dược Động Học :

▧ Route of Elimination :
A radiolabeled dose of encainide is excreted in approximately equal amounts in the urine and feces.
▧ Half Life :
1-2 hours
Chỉ Định : Encainide is a class Ic antiarrhythmic agent which was used for management of irregular heartbeats, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
Tương Tác Thuốc :
  • Cisapride Increased risk of cardiotoxicity and arrhythmias
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Enkaid
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01228
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06978
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0087-0732-41
PharmGKB
http://www.pharmgkb.org/drug/PA449459
Wikipedia
http://en.wikipedia.org/wiki/Encainide
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